• 1917 Citations
  • 25 h-Index
19982020

Research output per year

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Research Output

2020

In Vitro Studies to Define the Cell-Surface and Intracellular Targets of Polyarginine-Conjugated Sodium Borocaptate as a Potential Delivery Agent for Boron Neutron Capture Therapy

Fujimura, A., Yasui, S., Igawa, K., Ueda, A., Watanabe, K., Hanafusa, T., Ichikawa, Y., Yoshihashi, S., Tsuchida, K., Kamiya, A. & Furuya, S., Sep 23 2020, In : Cells. 9, 10

Research output: Contribution to journalArticle

Open Access

Sympathetic and parasympathetic innervation in cancer: therapeutic implications

Kamiya, A., Hiyama, T., Fujimura, A. & Yoshikawa, S., 2020, (Accepted/In press) In : Clinical Autonomic Research.

Research output: Contribution to journalReview article

2019

Genetic manipulation of autonomic nerve fiber innervation and activity and its effect on breast cancer progression

Kamiya, A., Hayama, Y., Kato, S., Shimomura, A., Shimomura, T., Irie, K., Kaneko, R., Yanagawa, Y., Kobayashi, K. & Ochiya, T., Aug 1 2019, In : Nature Neuroscience. 22, 8, p. 1289-1305 17 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Surface Modification with Lactadherin Augments the Attachment of Sonazoid Microbubbles to Glycoprotein IIb/IIIa

Otani, K., Kamiya, A., Miyazaki, T., Koga, A., Inatomi, A. & Harada-Shiba, M., Jun 2019, In : Ultrasound in Medicine and Biology. 45, 6, p. 1455-1465 11 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2018

Lumped parameter model for hemodynamic simulation of congenital heart diseases

Shimizu, S., Une, D., Kawada, T., Hayama, Y., Kamiya, A., Shishido, T. & Sugimachi, M., Mar 1 2018, In : Journal of Physiological Sciences. 68, 2, p. 103-111 9 p.

Research output: Contribution to journalReview article

7 Citations (Scopus)

Simplified Preparation of αvβ3 Integrin-Targeted Microbubbles Based on a Clinically Available Ultrasound Contrast Agent: Validation in a Tumor-Bearing Mouse Model

Otani, K., Nishimura, H., Kamiya, A. & Harada-Shiba, M., May 2018, In : Ultrasound in Medicine and Biology. 44, 5, p. 1063-1073 11 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Tonic aortic depressor nerve stimulation does not impede baroreflex dynamic characteristics concomitantly mediated by the stimulated nerve

Kawada, T., Turner, M. J., Shimizu, S., Kamiya, A., Shishido, T. & Sugimachi, M., Jan 1 2018, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 314, 3, p. R459-R467

Research output: Contribution to journalArticle

2 Citations (Scopus)
2017
2 Citations (Scopus)

Desipramine increases cardiac parasympathetic activity via α2-adrenergic mechanism in rats

Kawada, T., Akiyama, T., Shimizu, S., Fukumitsu, M., Kamiya, A. & Sugimachi, M., Jul 1 2017, In : Autonomic Neuroscience: Basic and Clinical. 205, p. 21-25 5 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Effects of different input pressure waveforms on the carotid sinus baroreflexmediated sympathetic arterial pressure response in rats

Kawada, T., Shimizu, S., Yamamoto, H., Miyamoto, T., Kamiya, A., Shishido, T. & Sugimachi, M., Oct 1 2017, In : Journal of Applied Physiology. 123, 4, p. 914-921 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Sodium ion transport participates in non-neuronal acetylcholine release in the renal cortex of anesthetized rabbits

Shimizu, S., Akiyama, T., Kawada, T., Sata, Y., Turner, M. J., Fukumitsu, M., Yamamoto, H., Kamiya, A., Shishido, T. & Sugimachi, M., Sep 1 2017, In : Journal of Physiological Sciences. 67, 5, p. 587-593 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

State-space representation of the extended Guyton’s model

Kamiya, A., Hayama, Y., Shimizu, S. & Kawada, T., Aug 11 2017, In : American Journal of Physiology - Heart and Circulatory Physiology. 313, 2, p. H320-H322

Research output: Contribution to journalEditorial

2016

Hybrid stage I palliation for hypoplastic left heart syndrome has no advantage on ventricular energetics: a theoretical analysis

Shimizu, S., Kawada, T., Une, D., Shishido, T., Kamiya, A., Sano, S. & Sugimachi, M., Jan 1 2016, In : Heart and Vessels. 31, 1, p. 105-113 9 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Partial cavopulmonary assist from the inferior vena cava to the pulmonary artery improves hemodynamics in failing Fontan circulation: a theoretical analysis

Shimizu, S., Kawada, T., Une, D., Fukumitsu, M., Turner, M. J., Kamiya, A., Shishido, T. & Sugimachi, M., May 1 2016, In : Journal of Physiological Sciences. 66, 3, p. 249-255 7 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2015

Acute effects of intravenous nifedipine or azelnidipine on open-loop baroreflex static characteristics in rats

Yamamoto, H., Kawada, T., Shimizu, S., Kamiya, A., Turner, M. J., Miyazaki, S. & Sugimachi, M., Apr 1 2015, In : Life Sciences. 126, p. 37-41 5 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Guanfacine enhances cardiac acetylcholine release with little effect on norepinephrine release in anesthetized rabbits

Shimizu, S., Kawada, T., Akiyama, T., Turner, M. J., Shishido, T., Kamiya, A., Shirai, M. & Sugimachi, M., Jan 1 2015, In : Autonomic Neuroscience: Basic and Clinical. 187, p. 84-87 4 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Predominant role of neural arc in sympathetic baroreflex resetting of spontaneously hypertensive rats: Analysis of an open-loop baroreflex equilibrium diagram

Sata, Y., Kawada, T., Shimizu, S., Kamiya, A., Akiyama, T. & Sugimachi, M., 2015, In : Circulation Journal. 79, 3, p. 592-599 8 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
2014

High-cut characteristics of the baroreflex neural arc in rats

Kawada, T., Shimizu, S., Li, M., Zheng, C., Uemura, K., Kamiya, A. & Sugimachi, M., Aug 17 2014, In : Transactions of Japanese Society for Medical and Biological Engineering. 52, p. O-406-O-407

Research output: Contribution to journalArticle

Medetomidine suppresses cardiac and gastric sympathetic nerve activities but selectively activates cardiac vagus nerve

Shimizu, S., Akiyama, T., Kawada, T., Kamiya, A., Turner, M. J., Yamamoto, H., Shishido, T., Shirai, M. & Sugimachi, M., 2014, In : Circulation Journal. 78, 6, p. 1405-1413 9 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Systems physiology of the baroreflex during orthostatic stress: From animals to humans

Kamiya, A., Kawada, T. & Sugimachi, M., 2014, In : Frontiers in Physiology. 5 JUL, 00256.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2013

Effects of cilnidipine on sympathetic outflow and sympathetic arterial pressure and heart rate regulations in rats

Yamamoto, H., Kawada, T., Shimizu, S., Kamiya, A., Miyazaki, S. & Sugimachi, M., Jul 10 2013, In : Life Sciences. 92, 24-26, p. 1202-1207 6 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

High-frequency dominant depression of peripheral vagal control of heart rate in rats with chronic heart failure

Kawada, T., Li, M., Shimizu, S., Kamiya, A., Uemura, K., Turner, M. J., Mizuno, M. & Sugimachi, M., Mar 2013, In : Acta Physiologica. 207, 3, p. 494-502 9 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Sympathetic afferent stimulation inhibits central vagal activation induced by intravenous medetomidine in rats

Kawada, T., Akiyama, T., Shimizu, S., Kamiya, A., Uemura, K., Turner, M. J., Shirai, M. & Sugimachi, M., Sep 2013, In : Acta Physiologica. 209, 1, p. 55-61 7 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2012

Adaptation of the respiratory controller contributes to the attenuation of exercise hyperpnea in endurance-trained athletes

Miyamoto, T., Inagaki, M., Takaki, H., Kawada, T., Shishido, T., Kamiya, A. & Sugimachi, M., Jan 2012, In : European Journal of Applied Physiology. 112, 1, p. 237-251 15 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Central vagal activation by alpha2-adrenergic stimulation is impaired in spontaneously hypertensive rats

Kawada, T., Akiyama, T., Shimizu, S., Kamiya, A., Uemura, K., Sata, Y., Shirai, M. & Sugimachi, M., Sep 2012, In : Acta Physiologica. 206, 1, p. 72-79 8 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Consideration on parameter determination of a new model describing dynamic vagal heart rate control in rats

Kawada, T., Uemura, K., Shimizu, S., Kamiya, A., Turner, M. J., Mizuno, M., Sunagawa, K. & Sugimachi, M., Dec 14 2012, 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2012. p. 3809-3812 4 p. 6346797. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Medetomidine, an α2-adrenergic agonist, activates cardiac vagal nerve through modulation of baroreflex control

Shimizu, S., Akiyama, T., Kawada, T., Sata, Y., Mizuno, M., Kamiya, A., Shishido, T., Inagaki, M., Shirai, M., Sano, S. & Sugimachi, M., Jan 2012, In : Circulation Journal. 76, 1, p. 152-159 8 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
2011

Centrally administered ghrelin activates cardiac vagal nerve in anesthetized rabbits

Shimizu, S., Akiyama, T., Kawada, T., Sonobe, T., Kamiya, A., Shishido, T., Tokudome, T., Hosoda, H., Shirai, M., Kangawa, K. & Sugimachi, M., Jul 5 2011, In : Autonomic Neuroscience: Basic and Clinical. 162, 1-2, p. 60-65 6 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Closed-loop spontaneous baroreflex transfer function is inappropriate for system identification of neural arc but partly accurate for peripheral arc: Predictability analysis

Kamiya, A., Kawada, T., Shimizu, S. & Sugimachi, M., Apr 2011, In : Journal of Physiology. 589, 7, p. 1769-1790 22 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Consideration on step duration to assess open-loop static characteristics of the carotid sinus baroreflex in rats

Kawada, T., Shimizu, S., Sata, Y., Kamiya, A., Sunagawa, K. & Sugimachi, M., Dec 26 2011, 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011. p. 689-692 4 p. 6090155. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Contrasting effects of moderate vagal stimulation on heart rate and carotid sinus baroreflex-mediated sympathetic arterial pressure regulation in rats

Kawada, T., Shimizu, S., Li, M., Kamiya, A., Uemura, K., Sata, Y., Yamamoto, H. & Sugimachi, M., Sep 26 2011, In : Life Sciences. 89, 13-14, p. 498-503 6 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Dynamic characteristics of baroreflex neural and peripheral arcs are preserved in spontaneously hypertensive rats

Kawada, T., Shimizu, S., Kamiya, A., Sata, Y., Uemura, K. & Sugimachi, M., Jan 1 2011, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 300, 1, p. R155-R165

Research output: Contribution to journalArticle

21 Citations (Scopus)

Exercise training augments the dynamic heart rate response to vagal but not sympathetic stimulation in rats

Mizuno, M., Kawada, T., Kamiya, A., Miyamoto, T., Shimizu, S., Shishido, T., Smith, S. A. & Sugimachi, M., Apr 1 2011, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 300, 4, p. R969-R977

Research output: Contribution to journalArticle

9 Citations (Scopus)

Involvement of the mechanoreceptors in the sensory mechanisms of manual and electrical acupuncture

Yamamoto, H., Kawada, T., Kamiya, A., Miyazaki, S. & Sugimachi, M., Feb 24 2011, In : Autonomic Neuroscience: Basic and Clinical. 160, 1-2, p. 27-31 5 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Norwood procedure with non-valved right ventricle to pulmonary artery shunt improves ventricular energetics despite the presence of diastolic regurgitation: A theoretical analysis

Shimizu, S., Une, D., Shishido, T., Kamiya, A., Kawada, T., Sano, S. & Sugimachi, M., Nov 2011, In : Journal of Physiological Sciences. 61, 6, p. 457-465 9 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2010

Both skeletonized and pedicled internal thoracic arteries supply adequate graft flow after coronary artery bypass grafting even during intense sympathoexcitation

Une, D., Shimizu, S., Kamiya, A., Kawada, T., Shishido, T. & Sugimachi, M., Nov 1 2010, In : Journal of Physiological Sciences. 60, 6, p. 407-413 7 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Dynamic characteristics of heart rate control by the autonomic nervous system in rats

Mizuno, M., Kawada, T., Kamiya, A., Miyamoto, T., Shimizu, S., Shishido, T., Smith, S. A. & Sugimachi, M., Sep 1 2010, In : Experimental Physiology. 95, 9, p. 919-925 7 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Estimated venous return surface and cardiac output curve precisely predicts new hemodynamics after volume change

Sugimachi, M., Sunagawa, K., Uemura, K., Kamiya, A., Shimizu, S., Inagaki, M. & Shishido, T., Dec 1 2010, 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10. p. 5205-5208 4 p. 5626268. (2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

In vivo direct monitoring of interstitial norepinephrine levels at the sinoatrial node

Shimizu, S., Akiyama, T., Kawada, T., Shishido, T., Mizuno, M., Kamiya, A., Yamazaki, T., Sano, S. & Sugimachi, M., Jan 15 2010, In : Autonomic Neuroscience: Basic and Clinical. 152, 1-2, p. 115-118 4 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Large conductance Ca2+-activated K+ channels inhibit vagal acetylcholine release at the rabbit sinoatrial node

Kawada, T., Akiyama, T., Shimizu, S., Kamiya, A., Uemura, K., Sata, Y., Shirai, M. & Sugimachi, M., Aug 1 2010, In : Autonomic Neuroscience: Basic and Clinical. 156, 1-2, p. 149-151 3 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Open-loop dynamic and static characteristics of the carotid sinus baroreflex in rats with chronic heart failure after myocardial infarction

Kawada, T., Li, M., Kamiya, A., Shimizu, S., Uemura, K., Yamamoto, H. & Sugimachi, M., Jul 1 2010, In : Journal of Physiological Sciences. 60, 4, p. 283-298 16 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Parallel resetting of arterial baroreflex control of renal and cardiac sympathetic nerve activities during upright tilt in rabbits

Kamiya, A., Kawada, T., Mizuno, M., Shimizu, S. & Sugimachi, M., Jun 1 2010, In : American Journal of Physiology - Heart and Circulatory Physiology. 298, 6, p. H1966-H1975

Research output: Contribution to journalArticle

5 Citations (Scopus)

Right ventricular stiffness constant as a predictor of postoperative hemodynamics in patients with hypoplastic right ventricle: A theoretical analysis

Shimizu, S., Shishido, T., Une, D., Kamiya, A., Kawada, T., Sano, S. & Sugimachi, M., May 2010, In : Journal of Physiological Sciences. 60, 3, p. 205-212 8 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2009

Angiotensin II disproportionally attenuates dynamic vagal and sympathetic heart rate controls

Kawada, T., Mizuno, M., Shimizu, S., Uemura, K., Kamiya, A. & Sugimachi, M., May 1 2009, In : American Journal of Physiology - Heart and Circulatory Physiology. 296, 5, p. H1666-H1674

Research output: Contribution to journalArticle

12 Citations (Scopus)

Detection of endogenous acetylcholine release during brief ischemia in the rabbit ventricle: A possible trigger for ischemic preconditioning

Kawada, T., Akiyama, T., Shimizu, S., Kamiya, A., Uemura, K., Li, M., Shirai, M. & Sugimachi, M., Oct 7 2009, In : Life Sciences. 85, 15-16, p. 597-601 5 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Feedback control of multiple hemodynamic variables with multiple cardiovascular drugs

Sugimachi, M., Uemura, K., Kamiya, A., Shimizu, S., Inagaki, M. & Shishido, T., Jan 1 2009, Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009. IEEE Computer Society, p. 2030-2032 3 p. 5334417. (Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

High levels of circulating angiotensin II shift the open-loop baroreflex control of splanchnic sympathetic nerve activity, heart rate and arterial pressure in anesthetized rats

Kawada, T., Kamiya, A., Li, M., Shimizu, S., Uemura, K., Yamamoto, H. & Sugimachi, M., Nov 1 2009, In : Journal of Physiological Sciences. 59, 6, p. 447-455 9 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

In vivo direct monitoring of vagal acetylcholine release to the sinoatrial node

Shimizu, S., Akiyama, T., Kawada, T., Shishido, T., Yamazaki, T., Kamiya, A., Mizuno, M., Sano, S. & Sugimachi, M., Jun 15 2009, In : Autonomic Neuroscience: Basic and Clinical. 148, 1-2, p. 44-49 6 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Macroscopic two-pump two-vasculature cardiovascular model to support treatment of acute heart failure

Sugimachi, M., Sunagawa, K., Uemura, K., Kamiya, A., Shimizu, S., Inagaki, M. & Shishido, T., Jan 1 2009, Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009. IEEE Computer Society, p. 2365-2368 4 p. 5335017. (Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Servo-controlled hind-limb electrical stimulation for short-term arterial pressure control

Kawada, T., Shimizu, S., Yamamoto, H., Shishido, T., Kamiya, A., Miyamoto, T., Sunagawa, K. & Sugimachi, M., May 1 2009, In : Circulation Journal. 73, 5, p. 851-859 9 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)