Akira Shimada

  • 1969 Citations
  • 22 h-Index
19972020

Research output per year

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Research Output

  • 1969 Citations
  • 22 h-Index
  • 104 Article
  • 22 Letter
  • 3 Comment/debate
  • 2 Review article
1997

Detection of heterozygous truncating mutations in the BRCA1 and APC genes by using a rapid screening assay in yeast

Ishioka, C., Suzuki, T., Fitzgerald, M., Krainer, M., Shimodaira, H., Shimada, A., Nomizu, T., Isselbacher, K. J., Haber, D. & Kanamaru, R., Mar 18 1997, In : Proceedings of the National Academy of Sciences of the United States of America. 94, 6, p. 2449-2453 5 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Differential contributions of BRCA1 and BRCA2 to early-onset breast cancer

Krainer, M., Silva-Arrieta, S., FitzGerald, M. G., Shimada, A., Ishioka, C., Kanamaru, R., MacDonald, D. J., Unsal, H., Finkelstein, D. M., Bowcock, A., Isselbacher, K. J. & Haber, D. A., May 28 1997, In : New England Journal of Medicine. 336, 20, p. 1416-1421 6 p.

Research output: Contribution to journalArticle

182 Citations (Scopus)

Oligomerization is not essential for growth suppression by p53 in p53-deficient osteosarcoma Saos-2 cells

Ishioka, C., Shimodaira, H., Englert, C., Shimada, A., Osada, M., Jia, L. Q., Suzuki, T., Gamo, M. & Kanamaru, R., Mar 6 1997, In : Biochemical and Biophysical Research Communications. 232, 1, p. 54-60 7 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
9 Citations (Scopus)
1998

Aberrant expression of double-stranded RNA-dependent protein kinase in hepatocytes of chronic hepatitis and differentiated hepatocellular carcinoma

Shimada, A., Shiota, G., Miyata, H., Kamahora, T., Kawasaki, H., Shiraki, K., Hino, S. & Terada, T., Oct 1 1998, In : Cancer Research. 58, 19, p. 4434-4438 5 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Detection of APC mutations by a yeast-based protein truncation test (YPTT)

Suzuki, T., Ishioka, C., Kato, S., Mitachi, Y., Shimodaira, H., Sakayori, M., Shimada, A., Asamura, M. & Kanamaru, R., Apr 23 1998, In : Genes Chromosomes and Cancer. 21, 4, p. 290-297 8 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
1999

Effects of p51/p63 missense mutations on transcriptional activities of p53 downstream gene promoters

Kato, S., Shimada, A., Osada, M., Ikawa, S., Obinata, M., Nakagawara, A., Kanamaru, R. & Ishioka, C., Dec 1 1999, In : Cancer Research. 59, 23, p. 5908-5911 4 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

The transcriptional activities of p53 and its homologue p51/p63: Similarities and differences

Shimada, A., Kato, S., Enjo, K., Osada, M., Ikawa, Y., Kohno, K., Obinata, M., Kanamaru, R., Ikawa, S. & Ishioka, C., Jun 15 1999, In : Cancer Research. 59, 12, p. 2781-2786 6 p.

Research output: Contribution to journalArticle

113 Citations (Scopus)
2002

Detection of ATM gene mutation in human glioma cell line M059J by a rapid frameshift/stop codon assay in yeast

Tsuchida, R., Yamada, T., Takagi, M., Shimada, A., Ishioka, C., Katsuki, Y., Igarashi, T., Chessa, L., Delia, D., Teraoka, H. & Mizutani, S., Jan 1 2002, In : Radiation Research. 158, 2, p. 195-201 7 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)
2003

Evaluation of the diagnostic accuracy of the stop codon (SC) assay for identifying protein-truncating mutations in the BRCA1 and BRCA2 genes in familial breast cancer

Sakayori, M., Kawahara, M., Shiraishi, K., Nomizu, T., Shimada, A., Kudo, T., Abe, R., Ohuchi, N., Takenoshita, S., Kanamaru, R. & Ishioka, C., 2003, In : Journal of Human Genetics. 48, 3, p. 130-137 8 p.

Research output: Contribution to journalArticle

Open Access
14 Citations (Scopus)

Successful clinical response to irinotecan in relapsed neuroblastoma

Shitara, T., Shimada, A., Tsuchida, Y., Suzuki, N., Toki, F. & Kuroiwa, M., Feb 1 2003, In : Medical and Pediatric Oncology. 40, 2, p. 126-128 3 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2004

Fetal origin of the GATA1 mutation in identical twins with transient myeloproliferative disorder and acute megakaryoblastic leukemia accompanying Down syndrome

Shimada, A., Xu, G., Toki, T., Kimura, H., Hayashi, Y. & Ito, E., Jan 1 2004, In : Blood. 103, 1, 1 p.

Research output: Contribution to journalLetter

41 Citations (Scopus)

Proinflammatory cytokinemia associated with transient myeloproliferative disorder in down syndrome

Shimada, A., Maruyama, K., Shitara, T., Kato, M., Cho, K., Kobayashi, T., Fujiu, T., Tsuchida, Y., Nishida, A., Hayashi, Y., Minakami, H., Kozawa, K. & Kimura, H., 2004, In : Biology of the Neonate. 85, 3, p. 167-172 6 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2005

Advanced-stage gastrointestinal stromal tumor treated with imatinib in a 12-year-old girl with a unique mutation of PDGFRA

Kuroiwa, M., Hiwatari, M., Hirato, J., Suzuki, N., Tsuchida, Y., Shimada, A., Shitara, T., Taki, T. & Hayashi, Y., Nov 2005, In : Journal of Pediatric Surgery. 40, 11, p. 1798-1801 4 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Oligoclonal expansion of T lymphocytes with multiple second-site mutations leads to Omenn syndrome in a patient with RAG1-deficient severe combined immunodeficiency

Wada, T., Toma, T., Okamoto, H., Kasahara, Y., Koizumi, S., Agematsu, K., Kimura, H., Shimada, A., Hayashi, Y., Kato, M. & Yachie, A., Sep 15 2005, In : Blood. 106, 6, p. 2099-2101 3 p.

Research output: Contribution to journalArticle

68 Citations (Scopus)

Pulmonary metastases after nephrectomy only for small, stage I/favorable-histology Wilms' tumor

Shitara, T., Tsuchida, Y., Hirato, J., Shimada, A., Murai, H., Suzuki, N., Kuroiwa, M. & Iwakawa, M., Jun 1 2005, In : Pediatric Surgery International. 21, 6, p. 470-473 4 p.

Research output: Contribution to journalArticle

2006

Irinotecan for children with relapsed solid tumors

Shitara, T., Shimada, A., Hanada, R., Matsunaga, T., Kawa, K., Mugishima, H., Sugimoto, T., Mimaya, J. I., Manabe, A., Tsurusawa, M. & Tsuchida, Y., Mar 2006, In : Pediatric Hematology and Oncology. 23, 2, p. 103-110 8 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

JAK2 mutation in a boy with polycythemia vera, but not in other pediatric hematologic disorders [8]

Park, M. J., Shimada, A., Asada, H., Koike, K., Tsuchida, M. & Hayashi, Y., Aug 2006, In : Leukemia. 20, 8, p. 1453-1454 2 p.

Research output: Contribution to journalLetter

9 Citations (Scopus)

KIT mutations, and not FLT3 internal tandem duplication, are strongly associated with a poor prognosis in pediatric acute myeloid leukemia with t(8;21): A study of the Japanese ChildhoodAMLCooperative Study Group

Shimada, A., Taki, T., Tabuchi, K., Tawa, A., Horibe, K., Tsuchida, M., Hanada, R., Tsukimoto, I. & Hayashi, Y., Mar 1 2006, In : Blood. 107, 5, p. 1806-1809 4 p.

Research output: Contribution to journalArticle

152 Citations (Scopus)

Mutations of the PTPN11 and RAS genes in rhabdomyosarcoma and pediatric hematological malignancies

Chen, Y., Takita, J., Hiwatari, M., Igarashi, T., Hanada, R., Kikuchi, A., Hongo, T., Taki, T., Ogasawara, M., Shimada, A. & Hayashi, Y., Jun 2006, In : Genes Chromosomes and Cancer. 45, 6, p. 583-591 9 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)

Omenn syndrome - Review of several phenotypes of Omenn syndrome and RAG1/RAG2 mutations in Japan

Kato, M., Kimura, H., Seki, M., Shimada, A., Hayashi, Y., Morio, T., Kumaki, S., Ishida, Y., Kamachi, Y. & Yachie, A., Jun 2006, In : Allergology International. 55, 2, p. 115-119 5 p.

Research output: Contribution to journalReview article

23 Citations (Scopus)
2007

AML1 mutation and FLT3-internal tandem duplication in leukemia transformed from myelodysplastic syndrome [1]

Shimada, A., Taketani, T., Kikuchi, A., Hanada, R., Arakawa, H., Kimura, H., Chen, Y. & Hayashi, Y., Sep 2007, In : Journal of Pediatric Hematology/Oncology. 29, 9, p. 666-667 2 p.

Research output: Contribution to journalLetter

1 Citation (Scopus)

Low frequency of KIT gene mutation in pediatric acute myeloid leukemia with inv(16)(p13q22): A study of the Japanese childhood AML cooperative study group [4]

Shimada, A., Ichikawa, H., Taki, T., Kubota, C., Hongo, T., Sako, M., Morimoto, A., Tawa, A., Tsukimoto, I. & Hayashi, Y., Oct 2007, In : International journal of hematology. 86, 3, p. 289-290 2 p.

Research output: Contribution to journalLetter

5 Citations (Scopus)

N822 mutation of KIT gene was frequent in pediatric acute myeloid leukemia patients with t(8;21) in Japan: A study of the Japanese childhood AML cooperative study group [15]

Shimada, A., Taki, T., Kubota, C., Itou, T., Tawa, A., Horibe, K., Tsuchida, M., Hanada, R., Tsukimoto, I. & Hayashi, Y., Oct 2007, In : Leukemia. 21, 10, p. 2218-2219 2 p.

Research output: Contribution to journalLetter

15 Citations (Scopus)

No nucleophosmin mutations in pediatric acute myeloid leukemia with normal karyotype: A study of the Japanese Childhood AML Cooperative Study Group [4]

Shimada, A., Taki, T., Kubota, C., Tawa, A., Horibe, K., Tsuchida, M., Hanada, R., Tsukimoto, I. & Hayashi, Y., Jun 2007, In : Leukemia. 21, 6, p. 1307 1 p.

Research output: Contribution to journalLetter

17 Citations (Scopus)

Pro-inflammatory cytokinemia is frequently found in Down syndrome patients with hematological disorders

Shimada, A., Hayashi, Y., Ogasawara, M., Park, M. J., Katoh, M., Minakami, H., Kitoh, T., Kojima, S., Kawa, K. & Kimura, H., Sep 2007, In : Leukemia Research. 31, 9, p. 1199-1203 5 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Spontaneous improvement of hematologic abnormalities in patients having juvenile myelomonocytic leukemia with specific RAS mutations

Matsuda, K., Shimada, A., Yoshida, N., Ogawa, A., Watanabe, A., Yajima, S., Iizuka, S., Koike, K., Yanai, F., Kawasaki, K., Yanagimachi, M., Kikuchi, A., Ohtsuka, Y., Hidaka, E., Yamauchi, K., Tanaka, M., Yanagisawa, R., Nakazawa, Y., Shiohara, M., Manabe, A. & 2 others, Kojima, S. & Koike, K., Jun 15 2007, In : Blood. 109, 12, p. 5477-5480 4 p.

Research output: Contribution to journalArticle

106 Citations (Scopus)
2008

Comparison of antitumor effects of multitargeted tyrosine kinase inhibitors in acute myelogenous leukemia

Hu, S., Niu, H., Minkin, P., Orwick, S., Shimada, A., Inaba, H., Dahl, G. V. H., Rubnitz, J. & Baker, S. D., 2008, In : Molecular cancer therapeutics. 7, 5, p. 1110-1120 11 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Expression of KIT and PDGFR is associated with a good prognosis in neuroblastoma

Shimada, A., Hirato, J., Kuroiwa, M., Kikuchi, A., Hanada, R., Wakai, K. & Hayashi, Y., Feb 2008, In : Pediatric Blood and Cancer. 50, 2, p. 213-217 5 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Hemophagocytic lymphohistiocytosis associated with uncontrolled inflammatory cytokinemia and chemokinemia was caused by systemic anaplastic large cell lymphoma: A case report and review of the literature

Shimada, A., Kato, M., Tamura, K., Hirato, J., Kanegane, H., Takechi, Y., Park, M. J., Sotomatsu, M., Hatakeyama, S. & Hayashi, Y., Oct 2008, In : Journal of Pediatric Hematology/Oncology. 30, 10, p. 785-787 3 p.

Research output: Contribution to journalLetter

14 Citations (Scopus)
3 Citations (Scopus)

Tandem duplications of MLL and FLT3 are correlated with poor prognoses in pediatric acute myeloid leukemia: A study of the Japanese childhood AML cooperative study group

Shimada, A., Taki, T., Tabuchi, K., Taketani, T., Hanada, R., Tawa, A., Tsuchida, M., Horibe, K., Tsukimoto, I. & Hayashi, Y., Feb 1 2008, In : Pediatric Blood and Cancer. 50, 2, p. 264-269 6 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)
2009

Age-associated difference in gene expression of paediatric acute myelomonocytic lineage leukaemia (FAB M4 and M5 subtypes) and its correlation with prognosis

Jo, A., Tsukimoto, I., Ishii, E., Asou, N., Mitani, S., Shimada, A., Igarashi, T., Hayashi, Y. & Ichikawa, H., Mar 1 2009, In : British Journal of Haematology. 144, 6, p. 917-929 13 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Manifestation of alveolar rhabdomyosarcoma as primary cutaneous lesions in a neonate with Beckwith-Wiedemann syndrome

Kuroiwa, M., Sakamoto, J., Shimada, A., Suzuki, N., Hirato, J., Park, M. J., Sotomatsu, M. & Hayashi, Y., Mar 1 2009, In : Journal of Pediatric Surgery. 44, 3, p. e31-e35

Research output: Contribution to journalArticle

11 Citations (Scopus)
2010

Down syndrome and GATA1 mutations in transient abnormal myeloproliferative disorder: Mutation classes correlate with progression to myeloid leukemia

Kanezaki, R., Toki, T., Terui, K., Xu, G., Wang, R. N., Shimada, A., Hama, A., Kanegane, H., Kawakami, K., Endo, M., Hasegawa, D., Kogawa, K., Adachi, S., Ikeda, Y., Iwamoto, S., Taga, T., Kosaka, Y., Kojima, S., Hayashi, Y. & Ito, E., Nov 25 2010, In : Blood. 116, 22, p. 4631-4638 8 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

FLT3-internal tandem duplication in a pediatric patient with t(8;21) acute myeloid leukemia

Kawamura, M., Kaku, H., Ito, T., Funata, N., Taki, T., Shimada, A. & Hayashi, Y., Dec 2010, In : Cancer Genetics and Cytogenetics. 203, 2, p. 292-296 5 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Prognostic significance of the BAALC isoform pattern and CEBPA mutations in pediatric acute myeloid leukemia with normal karyotype: A study by the Japanese Childhood AML Cooperative Study Group

Mizushima, Y., Taki, T., Shimada, A., Yui, Y., Hiraumi, Y., Matsubara, H., Watanabe, M., Watanabe, K. I., Kamitsuji, Y., Hayashi, Y., Tsukimoto, I., Kobayashi, R., Horibe, K., Tawa, A., Nakahata, T. & Adachi, S., Jun 2010, In : International journal of hematology. 91, 5, p. 831-837 7 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Prominent eosinophilia but less eosinophil activation in a patient with Omenn syndrome

Seki, M., Kimura, H., Mori, A., Shimada, A., Yamada, Y., Maruyama, K., Hayashi, Y., Agematsu, K., Morio, T., Yachie, A. & Kato, M., Aug 2010, In : Pediatrics International. 52, 4, p. e196-e199

Research output: Contribution to journalArticle

2 Citations (Scopus)

Sustained cytokinemia and chemokinemia concomitant with juvenile myelomonocytic leukemia in an infant with Noonan syndrome

Okazaki, K., Unemoto, J., Kondo, M., Kusaka, T., Kozawa, K., Yoshizumi, M., Shimada, A., Takita, J., Kaneko, T., Hama, T. & Kimura, H., Sep 2010, In : Leukemia Research. 34, 9, p. e226-e228

Research output: Contribution to journalLetter

2011

[Bone marrow findings of childhood aplastic anemia: analyses of 140 cases by central reviewers].

Hama, A., Yoshimi, A., Sakaguchi, H., Doisaki, S., Muramatsu, H., Shimada, A., Takahashi, Y., Nozawa, K., Ito, M., Tsuchida, M., Manabe, A., Ohara, A. & Kojima, S., Aug 2011, In : [Rinshō ketsueki] The Japanese journal of clinical hematology. 52, 8, p. 653-658 6 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Aberrant phosphorylation of STAT5 by granulocyte-macrophage colony-stimulating factor in infant cytomegalovirus infection mimicking juvenile myelomonocytic leukemia

Nishio, N., Takahashi, Y., Tanaka, M., Xu, Y., Yoshida, N., Sakaguchi, H., Doisaki, S., Hama, A., Muramatsu, H., Shimada, A. & Kojima, S., Sep 1 2011, In : Leukemia Research. 35, 9, p. 1261-1264 4 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

CD20-negative Epstein-Barr virus-associated post-transplant lymphoproliferative disease refractory to rituximab in a patient with severe aplastic anemia

Muramatsu, H., Takahashi, Y., Shimoyama, Y., Doisaki, S., Nishio, N., Ito, Y., Hama, A., Shimada, A., Yagasaki, H., Ito, M. & Kojima, S., Jun 1 2011, In : International journal of hematology. 93, 6, p. 779-781 3 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Excellent outcomes of children with CML treated with imatinib mesylate compared to that in pre-imatinib era

Muramatsu, H., Takahashi, Y., Sakaguchi, H., Shimada, A., Nishio, N., Hama, A., Doisaki, S., Yagasaki, H., Matsumoto, K., Kato, K. & Kojima, S., Feb 2011, In : International journal of hematology. 93, 2, p. 186-191 6 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Reduced-intensity conditioning for alternative donor hematopoietic stem cell transplantation in patients with dyskeratosis congenita

Nishio, N., Takahashi, Y., Ohashi, H., Doisaki, S., Muramatsu, H., Hama, A., Shimada, A., Yagasaki, H. & Kojima, S., Mar 1 2011, In : Pediatric Transplantation. 15, 2, p. 161-166 6 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)
2012

Autoimmune-like hepatitis following unrelated BMT successfully treated with rituximab

Narita, A., Muramatsu, H., Takahashi, Y., Sakaguchi, H., Doisaki, S., Nishio, N., Hama, A., Shimada, A., Ito, M. & Kojima, S., Apr 2012, In : Bone Marrow Transplantation. 47, 4, p. 600-602 3 p.

Research output: Contribution to journalLetter

6 Citations (Scopus)

Childhood acute myeloid leukemia with bone marrow eosinophilia caused by t(16;21)(q24;q22)

Kawashima, N., Shimada, A., Taketani, T., Hayashi, Y., Yoshida, N., Matsumoto, K., Takahashi, Y., Kojima, S. & Kato, K., May 1 2012, In : International journal of hematology. 95, 5, p. 577-580 4 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Clinical characteristics and outcome of refractory/relapsed myeloid leukemia in children with Down syndrome

Taga, T., Saito, A. M., Kudo, K., Tomizawa, D., Terui, K., Moritake, H., Kinoshita, A., Iwamoto, S., Nakayama, H., Takahashi, H., Tawa, A., Shimada, A., Taki, T., Kigasawa, H., Koh, K. & Adachi, S., Aug 30 2012, In : Blood. 120, 9, p. 1810-1815 6 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Congenital pancreatoblastoma associated with β-catenin mutation

Ismael, O., Shimada, A., Hama, A., Takahashi, Y., Sato, Y., Hayakawa, M., Tsuchiya, H., Tainaka, T., Ono, Y., Kaneko, K., Ando, H., Sato, K. & Kojima, S., May 2012, In : Pediatric Blood and Cancer. 58, 5, p. 827 1 p.

Research output: Contribution to journalLetter

4 Citations (Scopus)

De novo childhood myelodysplastic/myeloproliferative disease with unique molecular characteristics

Ismael, O., Shimada, A., Hama, A., Elshazley, M., Muramatsu, H., Goto, A., Sakaguchi, H., Tanaka, M., Takahashi, Y., Yinyan, X., Fukuda, M., Miyajima, Y., Yamashita, Y., Horibe, K., Hanada, R., Ito, M. & Kojima, S., Jul 2012, In : British Journal of Haematology. 158, 1, p. 129-137 9 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

DNMT3A mutations are rare in childhood acute myeloid leukaemia, myelodysplastic syndromes and juvenile myelomonocytic leukaemia

Shiba, N., Taki, T., Park, M. J., Shimada, A., Sotomatsu, M., Adachi, S., Tawa, A., Horibe, K., Tsuchida, M., Hanada, R., Tsukimoto, I., Arakawa, H. & Hayashi, Y., Feb 2012, In : British Journal of Haematology. 156, 3, p. 413-414 2 p.

Research output: Contribution to journalLetter

17 Citations (Scopus)