Neutron Therapy Research Center

Research Output

1999

Modulation of T cell function by alpha-fetoprotein: An in vivo study on porcine thyroid peroxidase-induced experimental autoimmune thyroiditis in transgenic mice producing human alpha-fetoprotein

Matsuura, E., Kang, Y., Kitakawa, H., Ogata, A., Kotani, T., Ohtaki, S. & Nishi, S., May 1999, In : Tumor Biology. 20, 3, p. 162-171 10 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Replication of hepatitis B virus which carries foreign DNA in vitro

Hanafusa, T., Yumoto, Y., Hada, H., Shinji, T., Koide, N. & Tsuji, T., Aug 27 1999, In : Biochemical and Biophysical Research Communications. 262, 2, p. 530-533 4 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Single amino acid replacements in an antigenic peptide are sufficient to alter the TCR Vβ repertoire of the responding CD8+ cytotoxic lymphocyte population

Kalergis, A. M., Ono, T., Wang, F., DiLorenzo, T. P., Honda, S. & Nathenson, S. G., Jun 15 1999, In : Journal of Immunology. 162, 12, p. 7263-7270 8 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Synchronous expression of contractile proteins in mesangial cells and interstitial cells in IgA nephropathy

Kanao, K., Kashihara, N., Yamasaki, Y., Sugiyama, H., Okamoto, K., Maeshima, Y., Matsui, H. & Makino, H., 1999, In : Clinical and Experimental Nephrology. 3, 4, p. 279-289 11 p.

Research output: Contribution to journalArticle

β2-glycoprotein I is necessary to inhibit protein C activity by monoclonal anticardiolipin antibodies

Ieko, M., Ichikawa, K., Triplett, D. A., Matsuura, E., Atsumi, T., Sawada, K. I. & Koike, T., Jan 1999, In : Arthritis and Rheumatism. 42, 1, p. 167-174 8 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)
1998

A 50-kDa variant form of human surfactant protein D

Mason, R. J., Nielsen, L. D., Kuroki, Y., Matsuura, E., Freed, J. H. & Shannon, J. M., Nov 1998, In : European Respiratory Journal. 12, 5, p. 1147-1155 9 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

A calcineurin inhibitor, FK506, blocks voltage-gated calcium channel-dependent LTP in the hippocampus

Onuma, H., Lu, Y. F., Tomizawa, K., Moriwaki, A., Tokuda, M., Hatase, O. & Matsui, H., Apr 1 1998, In : Neuroscience Research. 30, 4, p. 313-319 7 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Alterations in TCR-MHC contacts subsequent to cross-recognition of class I MHC and singly substituted peptide variants

Ono, T., DiLorenzo, T. P., Wang, F., Kalergis, A. M. & Nathenson, S. G., Nov 15 1998, In : Journal of Immunology. 161, 10, p. 5454-5463 10 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

An immunosuppressant, FK506, protects against neuronal dysfunction and death but has no effect on electrographic and behavioral activities induced by systemic kainate

Moriwaki, A., Lu, Y. F., Tomizawa, K. & Matsui, H., Jun 8 1998, In : Neuroscience. 86, 3, p. 855-865 11 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Antiphospholipid antibodies and atherosclerosis

Matsuura, E., Kobayashi, K., Yasuda, T. & Koike, T., 1998, In : Lupus. 7, SUPPL. 2

Research output: Contribution to journalArticle

32 Citations (Scopus)

Anti-β2-glycoprotein I antibodies

Tsutsumi, A., Ichikawa, K., Matsuura, E. & Koike, T., 1998, In : Lupus. 7, SUPPL. 2

Research output: Contribution to journalArticle

9 Citations (Scopus)

Epitopes on β2-GPI recognized by anticardiolipin antibodies

Koike, T., Ichikawa, K., Kasahara, H., Atsumi, T., Tsutsumi, A. & Matsuura, E., 1998, In : Lupus. 7, SUPPL. 2

Research output: Contribution to journalArticle

41 Citations (Scopus)

Expression of cyclin-dependent kinase 5 and associated cyclins in Leydig and sertoli cells of the testis

Musa, F. R. M., Tokuda, M., Kuwata, Y., Ogawa, T., Tomizawa, K., Konishi, R., Takenaka, I. & Hatase, O., Dec 1 1998, In : Journal of Andrology. 19, 6, p. 657-666 10 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Major histocompatibility complex class I-restricted T cells are required for all but the end stages of diabetes development in nonobese diabetic mice and use a prevalent T cell receptor α chain gene rearrangement

DiLorenzo, T. P., Graser, R. T., Ono, T., Christianson, G. J., Chapman, H. D., Roopenian, D. C., Nathenson, S. G. & Serreze, D. V., Oct 13 1998, In : Proceedings of the National Academy of Sciences of the United States of America. 95, 21, p. 12538-12543 6 p.

Research output: Contribution to journalArticle

156 Citations (Scopus)

Physiological role of calcineurin in central nervous system

Matsui, H., Lu, Y. F. & Moriwaki, A., 1998, In : Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme. 43, 8 Suppl, p. 1039-1046 8 p.

Research output: Contribution to journalArticle

Point mutations in the S and pre-S2 genes observed in two hepatitis B virus carriers positive for antibody to hepatitis B surface antigen

Shinji, T., Koide, N., Hanafusa, T., Hada, H., Oka, T., Takayama, N., Shiraha, H., Nakamura, M., Ujike, K., Yumoto, Y. & Tsuji, T., 1998, In : Hepato-Gastroenterology. 45, 20, p. 500-502 3 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Vaccination with multiple antigen peptide as rejection antigen peptide in murine leukemia

Manki, A., Ono, T., Uenaka, A., Seino, Y. & Nakayama, E., May 1 1998, In : Cancer Research. 58, 9, p. 1960-1964 5 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
1997

Changes in serum concentrations of matrix metalloproteinases, tissue inhibitors of metalloproteinases and type IV collagen in patients with various types of glomerulonephritis

Akiyama, K., Shikata, K., Sugimoto, H., Matsuda, M., Shikata, Y., Fujimoto, N., Obata, K., Matsui, H. & Makino, H., 1997, In : Research Communications in Molecular Pathology and Pharmacology. 95, 2, p. 115-128 14 p.

Research output: Contribution to journalArticle

57 Citations (Scopus)

Changes in the expression of novel Cdk5 activator messenger RNA (p39(nck5ai) mRNA) during rat brain development

Cai, X. H., Tomizawa, K., Tang, D., Lu, Y. F., Moriwaki, A., Tokuda, M., Nagahata, S., Hatase, O. & Matsui, H., Aug 1997, In : Neuroscience Research. 28, 4, p. 355-360 6 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)
17 Citations (Scopus)

Diversity of epitopes recognized by cytotoxic T lymphocytes that are specific for rejection antigen peptide pRL1a presented on BALB/c leukemia RL♂1

Yokoi, T., Uenaka, A., Ono, T., Onizuka, S., Inoue, H. & Nakayama, E., 1997, In : International Immunology. 9, 8, p. 1195-1201 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Effects of vasopressin and involvement of receptor subtypes in the rat central amygdaloid nucleus in vitro

Lu, Y. F., Moriwaki, A., Tomizawa, K., Onuma, H., Cai, X. H. & Matsui, H., Sep 12 1997, In : Brain Research. 768, 1-2, p. 266-272 7 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Involvement of calmodulin-dependent protein kinases-I and -IV in long-term potentiation

Tokuda, M., Ahmed, B. Y., Lu, Y. F., Matsui, H., Miyamoto, O., Yamaguchi, F., Konishi, R. & Hatase, O., Apr 25 1997, In : Brain Research. 755, 1, p. 162-166 5 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Reciprocal gene expression of rat fibroglycan and β-actin during the course of regeneration after D-galactosamine liver injury

Shinji, T., Koide, N., Hada, H., Sasaki, S., Oka, T., Takayama, N., Shiraha, H., Ujike, K., Nakamura, M., Hanafusa, T., Yumoto, Y. & Tsuji, T., 1997, In : Hepato-Gastroenterology. 44, 13, p. 239-244 6 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Reticalmin: A novel calcium-calmodulin-dependent protein kinase IV-like protein in rat retina

Hirooka, K., Tokuda, M., Tsumura, T., Ahmed, B. Y., Itano, T., Matsui, H., Konishi, R., Hasegawa, E., Okuno, S., Kitani, T., Fujisawa, H. & Hatase, O., Aug 1997, In : Vision Research. 37, 15, p. 2029-2033 5 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
1996

Calcineurin inhibitors, FK506 and cyclosporin A, suppress the NMDA receptor-mediated potentials and LTP, but not depotentiation in the rat hippocampus

Lu, Y. F., Tomizawa, K., Moriwaki, A., Hayashi, Y., Tokuda, M., Itano, T., Hatase, O. & Matsui, H., Aug 5 1996, In : Brain Research. 729, 1, p. 142-146 5 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)

Developmental alteration of the expression and kinase activity of cyclin-dependent kinase 5 (Cdk5)/p35(nck5a) in the rat retina

Hirooka, K., Tomizawa, K., Matsui, H., Tokuda, M., Itano, T., Hasegawa, E., Wang, J. H. & Hatase, O., Dec 1996, In : Journal of Neurochemistry. 67, 6, p. 2478-2483 6 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Developmental alternation of the expression and kinase activity of Cyclin-dependent kinase (Cdk)5/P35nck5a in the rat retina

Hirooka, K., Tomizawa, K., Tokuda, M., Matsui, H., Matsuoka, T., Hatase, O. & Hasegawa, E., Feb 15 1996, In : Investigative Ophthalmology and Visual Science. 37, 3

Research output: Contribution to journalArticle

Distinct cellular compartment of cyclin-dependent kinase 5 (Cdk5) and neuron-specific Cdk5 activator protein (p35(nck5a)) in the developing rat cerebellum

Matsushita, M., Tomizawa, K., Yun-Fei, L., Moriwaki, A., Tokuda, M., Itano, T., Wang, J. H., Hatase, O. & Matsui, H., Sep 23 1996, In : Brain Research. 734, 1-2, p. 319-322 4 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Effects of neurotensin on neurons in the rat central amygdaloid nucleus in vitro

Lu, Y. F., Moriwaki, A., Hayashi, Y., Tomizawa, K., Itano, T. & Matsui, H., 1996, In : Brain Research Bulletin. 40, 2, p. 135-141 7 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

FK506, a Ca2+/calmodulin-dependent phosphatase inhibitor, inhibits the induction of long-term potentiation in the rat hippocampus

Lu, Y. F., Hayashi, Y., Moriwaki, A., Tomizawa, K. & Matsui, H., Feb 23 1996, In : Neuroscience Letters. 205, 2, p. 103-106 4 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Immunosuppressant FK506 prevents messy fiber sprouting induced by kindling stimulation

Moriwaki, A., Lu, Y. F., Hayashi, Y., Tomizawa, K., Tokuda, M., Itano, T., Hatase, O. & Matsui, H., Jun 1996, In : Neuroscience Research. 25, 2, p. 191-194 4 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Localization and developmental changes in the neuron-specific cyclin- dependent kinase 5 activator (p35(nck5a)) in the rat brain

Tomizawa, K., Matsui, H., Matsushita, M., Lew, J., Tokuda, M., Itano, T., Konishi, R., Wang, J. H. & Hatase, O., Jul 19 1996, In : Neuroscience. 74, 2, p. 519-529 11 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

Production of murine leukemia RL♂1 rejection antigen peptide pRL1a by proteolysis of natural precursor pRL1b

Ono, T., Uenaka, A. & Nakayama, E., Nov 1996, In : Japanese Journal of Cancer Research. 87, 11, p. 1165-1170 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
1995

Developmental changes of cyclin dependent kinase 5 subcellular localization in the rat cerebellum

Matsushita, M., Matsui, H., Itano, T., Tomizawa, K., Tokuda, M., Suwaki, H., Wang, J. H. & Hatase, O., 1995, In : NeuroReport. 6, 9, p. 1267-1270 4 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Identification of Rap 1 as a target for the Crk SH3 domain-binding guanine nucleotide-releasing factor C3G

Gotoh, T., Hattori, S., Nakamura, S., Kitayama, H., Noda, M., Takai, Y., Kaibuchi, K., Matsui, H., Hatase, O., Takahashi, H., Kurata, T. & Matsuda, M., Dec 1995, In : Molecular and Cellular Biology. 15, 12, p. 6746-6753 8 p.

Research output: Contribution to journalArticle

317 Citations (Scopus)

Loss of heterozygosity and analysis of mutation of p53 in hepatocellular carcinoma

Yumoto, Y., Hanafusa, T., Hada, H., Morita, T., Ooguchi, S., Shinji, N., Mitani, T., Hamaya, K., Koide, N. & Tsuji, T., 1995, In : Journal of Gastroenterology and Hepatology (Australia). 10, 2, p. 179-185 7 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)

Requirement of CD4+ T cells and antigen-presenting cells for primary in vitro generation of CD8+ cytotoxic T cells against L(d)-binding self-peptide p2Ca

Wada, H., Ono, T., Uenaka, A., Monden, M. & Nakayama, E., 1995, In : Immunology. 84, 4, p. 633-637 5 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
1994

Anticardiolipin antibodies recognize β2-glycoprotein I structure altered by interacting with an oxygen modified solid phase surface

Matsuura, E., Igarashi, Y., Yasuda, T., Triplett, D. A. & Koike, T., Feb 1 1994, In : Journal of Experimental Medicine. 179, 2, p. 457-462 6 p.

Research output: Contribution to journalArticle

544 Citations (Scopus)

Estimation of remnant liver function before hepatectomy by means of technetium-99m-diethylenetriamine-pentaacetic acid galactosyl human albumin

Yumoto, Y., Umeda, M., Ohshima, K., Ogawa, H., Kurokawa, T., Kajitani, M., Yumoto, E., Hanafusa, T., Tsuboi, H., Higashi, T., Mitani, T. & Tsuji, T., Jan 1994, In : Cancer Chemotherapy and Pharmacology. 33, 1 Supplement

Research output: Contribution to journalArticle

23 Citations (Scopus)

Identification of a unique antigen peptide pRL1 on BALB/c RL♂1 leukemia recognized by cytotoxic T lymphocytes and its relation to the Akt oncogene

Uenaka, A., Ono, T., Akisawa, T., Wada, H., Yasuda, T. & Nakayama, E., Nov 1 1994, In : Journal of Experimental Medicine. 180, 5, p. 1599-1607 9 p.

Research output: Contribution to journalArticle

83 Citations (Scopus)
1993

Classification of hepatitis C virus into subgroups on the basis of sequence variations in the envelope protein

HADA, H., KOIDE, N., Hanafusa, T., TAKABATAKE, H., SAKAGUCHI, K., SHINJI, T., SASAKI, S., OKA, T., TAKAYAMA, N., YUMOTO, Y. & TSUJI, T., 1993, In : Journal of Gastroenterology and Hepatology. 8, 1 S, p. S70-S74

Research output: Contribution to journalArticle

1 Citation (Scopus)

Clonal analysis of human T-cell responses to fractionated house dust mite antigens (Dermatophagoides pteronyssinus)

Okano, M., Nagano, T., Ono, T., Masuda, Y. & Ohta, N., 1993, In : International Archives of Allergy and Immunology. 101, 1, p. 82-88 7 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Nucleotide sequence and regulated expression of the Salmonella fljA gene encoding a repressor of the phase 1 flagellin gene

Hanafusa, T., Saito, K., Tominaga, A. & Enomoto, M., Jan 1993, In : MGG Molecular & General Genetics. 236, 2-3, p. 260-266 7 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
1992
9 Citations (Scopus)

Detection by western blotting of an antibody to the hepatitis C virus E1 envelope protein in sera of patients with chronic liver disease.

Hada, H., Koide, N., Hanafusa, T., Sakaguchi, K., Shinji, T., Sasaki, S., Oka, T., Takayama, N., Yumoto, Y. & Tsuji, T., Oct 1992, In : Acta Medica Okayama. 46, 5, p. 365-370 6 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Heterogeneity of anticardiolipin antibodies defined by the anticardiolipin cofactor

Matsuura, E., Igarashi, Y., Fujimoto, M., Ichikawa, K., Suzuki, T., Sumida, T., Yasuda, T. & Koike, T., Jun 15 1992, In : Journal of Immunology. 148, 12, p. 3885-3891 7 p.

Research output: Contribution to journalArticle

313 Citations (Scopus)

Integration of SCP1, a giant linear plasmid, into the Streptomyces coelicolor chromosome

Kinashi, H., Shimaji-Murayama, M. & Hanafusa, T., Jun 15 1992, In : Gene. 115, 1-2, p. 35-41 7 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Magnocellular neurosecretory neurons with ferritin-like immunoreactivity in the hypothalamic supraoptic and paraventricular nuclei of the rat

Tokunaga, A., Ono, K., Ono, T. & Ogawa, M., Nov 27 1992, In : Brain Research. 597, 1, p. 170-175 6 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Treatment of hepatocellular carcinoma by transcatheter hepatic arterial injection of radioactive iodized oil solution

Yumoto, Y., Jinno, K., Inatsuki, S., Moriwaki, S., Hanafusa, T., Yumoto, E., Slriota, T., Higashi, T., Koide, N., Hada, H., Murase, K., Hamamoto, K. & Tsuji, T., Jan 1992, In : Cancer Chemotherapy and Pharmacology. 31, 1 Supplement

Research output: Contribution to journalArticle

16 Citations (Scopus)