Neutron Therapy Research Center

Research Output 1977 2019

2019

A culture substratum with net-like polyamide fibers promotes the differentiation of mouse and human pluripotent stem cells to insulin-producing cells

Kaitsuka, T., Kojima, R., Kawabe, M., Noguchi, H., Shiraki, N., Kume, S. & Tomizawa, K., Jun 19 2019, In : Biomedical materials (Bristol, England). 14, 4, 1 p.

Research output: Contribution to journalArticle

Insulin
Nylons
Stem cells
Polyamides
Fibers

A leucine zipper-based peptide hybrid delivers functional Nanog protein inside the cell nucleus

Hakata, Y., Michiue, H., Ohtsuki, T., Miyazawa, M. & Kitamatsu, M., Jan 1 2019, In : Bioorganic and Medicinal Chemistry Letters.

Research output: Contribution to journalArticle

Leucine Zippers
Cell Nucleus
Cell-Penetrating Peptides
Cells
Peptides

Mutants of β2-glycoprotein I: Their features and potent applications

Shen, L., Azmi, N. U., Tan, X. W., Yasuda, S., Wahyuningsih, A. T., Inagaki, J., Kobayashi, K., Ando, E., Sasaki, T. & Matsuura, E., Jan 1 2019, In : Best Practice and Research: Clinical Rheumatology.

Research output: Contribution to journalReview article

Glycoproteins
Cardiolipins
Plasminogen
Fibrinolysin
Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry
1 Citation (Scopus)

Novel single-chain variant of antibody against mesothelin established by phage library

Yakushiji, H., Kobayashi, K., Takenaka, F., Kishi, Y., Shinohara, M., Akehi, M., Sasaki, T., Ohno, E. & Matsuura, E., Sep 1 2019, In : Cancer Science. 110, 9, p. 2722-2733 12 p.

Research output: Contribution to journalArticle

Open Access
Single-Chain Antibodies
Bacteriophages
Clone Cells
Positron-Emission Tomography
Neoplasms
1 Citation (Scopus)

Oxytocin and Stress: Neural Mechanisms, Stress-Related Disorders, and Therapeutic Approaches

Matsushita, H., Latt, H. M., Koga, Y., Nishiki, T. & Matsui, H., Oct 1 2019, In : Neuroscience. 417, p. 1-10 10 p.

Research output: Contribution to journalArticle

Oxytocin
Hippocampus
Glucocorticoids
Hypothalamus
Oxytocin Receptors
6 Citations (Scopus)

Use of DNA-generated gold nanoparticles to radiosensitize and eradicate radioresistant glioma stem cells

Kunoh, T., Shimura, T., Kasai, T., Matsumoto, S., Mahmud, H., Khayrani, A. C., Seno, M., Kunoh, H. & Takada, J., Feb 1 2019, In : Nanotechnology. 30, 5, 055101.

Research output: Contribution to journalArticle

Stem cells
Gold
DNA
Nanoparticles
Cell death
2018
1 Citation (Scopus)

Boron Neutron Capture Therapy Combined with Early Successive Bevacizumab Treatments for Recurrent Malignant Gliomas - A Pilot Study

Shiba, H., Takeuchi, K., Hiramatsu, R., Furuse, M., Nonoguchi, N., Kawabata, S., Kuroiwa, T., Kondo, N., Sakurai, Y., Suzuki, M., Ono, K., Oue, S., Ishikawa, E., Michiue, H. & Miyatake, S. I., Dec 15 2018, In : Neurologia Medico-Chirurgica. 58, 12, p. 487-494 8 p.

Research output: Contribution to journalArticle

Boron Neutron Capture Therapy
Glioma
Radiation
Necrosis
Brain
Cardiac Myocytes
Inhibitory Concentration 50
Medicine
Rats
Reading
8 Citations (Scopus)

Fibroblast growth factor 13 regulates glioma cell invasion and is important for bevacizumab-induced glioma invasion

Otani, Y., Ichikawa, T., Kurozumi, K., Inoue, S., Ishida, J., Oka, T., Shimizu, T., Tomita, Y., Hattori, Y., Uneda, A., Matsumoto, Y., Michiue, H. & Date, I., Feb 8 2018, In : Oncogene. 37, 6, p. 777-786 10 p.

Research output: Contribution to journalArticle

Glioma
Glioblastoma
Cell Line
Tubulin
Stem Cells
2 Citations (Scopus)

Oxytocin Inhibits Corticosterone-induced Apoptosis in Primary Hippocampal Neurons

Latt, H. M., Matsushita, H., Morino, M., Koga, Y., Michiue, H., Nishiki, T., Tomizawa, K. & Matsui, H., May 21 2018, In : Neuroscience. 379, p. 383-389 7 p.

Research output: Contribution to journalArticle

Oxytocin
Corticosterone
Apoptosis
Neurons
Neuroglia
Drug Delivery Systems
Technology
Small Interfering RNA
Antibodies
Apoptosis

Physical modification of carbon nanotubes with a dendrimer bearing terminal mercaptoundecahydrododecaborates (Na2B12H11S)

Yamagami, M., Tajima, T., Ishimoto, K., Miyake, H., Michiue, H. & Takaguchi, Y., Jan 1 2018, (Accepted/In press) In : Heteroatom Chemistry. e21467.

Research output: Contribution to journalArticle

Bearings (structural)
Dendrimers
Carbon Nanotubes
Boron
Single-walled carbon nanotubes (SWCN)
3 Citations (Scopus)

Regulation of mitochondrial iron homeostasis by sideroflexin 2

Mon, E. E., Wei, F. Y., Ahmad, R. N. R., Yamamoto, T., Moroishi, T. & Tomizawa, K., Jan 1 2018, (Accepted/In press) In : Journal of Physiological Sciences.

Research output: Contribution to journalArticle

Homeostasis
Iron
Heme
Mitochondrial Proteins
Enzymes
1 Citation (Scopus)

Suppression effect on IFN-γ of adipose tissue-derived mesenchymal stem cells isolated from β2-microglobulin-deficient mice

Masuda, J., Takayama, E., Ichinohe, T., Strober, W., Mizuno-Kamiya, M., Ikawa, T., Kitani, A., Kawaki, H., Fuss, I., Kawamoto, H., Seno, A., Vaidyanath, A., Umemura, N., Mizutani, A., Kasai, T., Honjo, Y., Satoh, A., Murakami, H., Katsura, Y., Kondoh, N. & 1 others, Seno, M., Nov 1 2018, In : Experimental and Therapeutic Medicine. 16, 5, p. 4277-4282 6 p.

Research output: Contribution to journalArticle

Graft vs Host Disease
Mesenchymal Stromal Cells
Interferons
Adipose Tissue
Major Histocompatibility Complex
2017
1 Citation (Scopus)

Anti-high Mobility Group Box 1 Antibody Ameliorates Albuminuria in MRL/lpr Lupus-Prone Mice

Watanabe, H., Watanabe, K. S., Liu, K., Hiramatsu, S., Zeggar, S., Katsuyama, E., Tatebe, N., Akahoshi, A., Takenaka, F., Hanada, T., Akehi, M., Sasaki, T., Sada, K., Matsuura, E., Nishibori, M. & Wada, J., Sep 15 2017, In : Molecular Therapy - Methods and Clinical Development. 6, p. 31-39 9 p.

Research output: Contribution to journalArticle

Albuminuria
Monoclonal Antibodies
Antibodies
Neutrophil Infiltration
Kidney
1 Citation (Scopus)

In vitro analysis of radioprotective effect of monoterpenes

Kudo, K. I., Hanafusa, T. & Ono, T., May 4 2017, (Accepted/In press) In : Journal of Radioanalytical and Nuclear Chemistry. p. 1-6 6 p.

Research output: Contribution to journalArticle

Monoterpenes
DNA
Isoprene
Oxygen
Antioxidants
3 Citations (Scopus)

PIK3R1Met326Ile germline mutation correlates with cysteine-rich protein 61 expression and poor prognosis in glioblastoma

Otani, Y., Ishida, J., Kurozumi, K., Oka, T., Shimizu, T., Tomita, Y., Hattori, Y., Uneda, A., Matsumoto, Y., Michiue, H., Tomida, S., Matsubara, T., Ichikawa, T. & Date, I., Dec 1 2017, In : Scientific Reports. 7, 1, 7391.

Research output: Contribution to journalArticle

Cysteine-Rich Protein 61
Germ-Line Mutation
Glioblastoma
Survival
Brain Neoplasms
4 Citations (Scopus)

The lipid moiety 7-ketocholesteryl-9-carboxynonanoate mediates binding interaction of oxLDL to LOX-1 and upregulates ABCA1 expression through PPARγ

Li, J., Xiu, Z., Wang, R., Yu, C., Chi, Y., Qin, J., Fu, C., Matsuura, E. & Liu, Q., May 15 2017, In : Life Sciences. 177, p. 27-40 14 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Up-Regulation
Lipids
Assays
Immunosorbents
2015
11 Citations (Scopus)

A combination of YM-155, a small molecule survivin inhibitor, and IL-2 potently suppresses renal cell carcinoma in murine model

Guo, K., Huang, P., Xu, N., Xu, P., Kaku, H., Zheng, S., Xu, A., Matsuura, E., Liu, C. & Kumon, H., 2015, In : Oncotarget. 6, 25, p. 21136-21147 12 p.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Interleukin-2
Lung
Kidney
Neoplasms
10 Citations (Scopus)

A finite difference method for elastic wave scattering by a planar crack with contacting faces

Kimoto, K. & Ichikawa, Y., Jan 1 2015, In : Wave Motion. 52, p. 120-137 18 p.

Research output: Contribution to journalArticle

wave scattering
elastic waves
elastic scattering
cracks
crack opening displacement

A new theoretical mineral dissolution rate equation for physicochemical factors

Choi, J., Ichikawa, Y., Kimoto, K. & Chae, B. G., 2015, In : Geochemical Journal. 49, 5, p. 549-557 9 p.

Research output: Contribution to journalArticle

Minerals
dissolving
Dissolution
dissolution
minerals
23 Citations (Scopus)

Annexin A2 regulates angiogenesis and invasion phenotypes of malignant glioma

Onishi, M., Ichikawa, T., Kurozumi, K., Inoue, S., Maruo, T., Otani, Y., Fujii, K., Ishida, J., Shimazu, Y., Yoshida, K., Michiue, H., Antonio Chiocca, E. & Date, I., Feb 20 2015, In : Brain Tumor Pathology. 32, 3, p. 184-194 11 p.

Research output: Contribution to journalArticle

Annexin A2
Glioma
Phenotype
Platelet-Derived Growth Factor
Glioblastoma
4 Citations (Scopus)

A novel leucine zipper motif-based hybrid peptide delivers a functional peptide cargo inside cells

Hakata, Y., Tsuchiya, S., Michiue, H., Ohtsuki, T., Matsui, H., Miyazawa, M. & Kitamatsu, M., Jan 7 2015, In : Chemical Communications. 51, 2, p. 413-416 4 p.

Research output: Contribution to journalArticle

Cell-Penetrating Peptides
Leucine Zippers
Fasteners
Autophagy
Cell death
11 Citations (Scopus)

A novel PET imaging using 64cu-labeled monoclonal antibody against mesothelin commonly expressed on cancer cells

Kobayashi, K., Sasaki, T., Takenaka, F., Yakushiji, H., Fujii, Y., Kishi, Y., Kita, S., Shen, L., Kumon, H. & Matsuura, E., 2015, In : Journal of Immunology Research. 2015, 268172.

Research output: Contribution to journalArticle

Positron-Emission Tomography
Monoclonal Antibodies
Neoplasms
Nude Mice
Pleura

Ca2+ sensors: Synaptotagmins

Nishiki, T., Kuroki, K., Masumoto, T. & Matsui, H., Jan 1 2015, Presynaptic Terminals. Springer Japan, p. 167-194 28 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Synaptotagmins
Sensors
Fusion reactions
Synaptic Vesicles
Membranes
36 Citations (Scopus)

Cdk5rap1-mediated 2-methylthio modification of mitochondrial tRNAs governs protein translation and contributes to myopathy in mice and humans

Wei, F. Y., Zhou, B., Suzuki, T., Miyata, K., Ujihara, Y., Horiguchi, H., Takahashi, N., Xie, P., Michiue, H., Fujimura, A., Kaitsuka, T., Matsui, H., Koga, Y., Mohri, S., Suzuki, T., Oike, Y. & Tomizawa, K., Mar 3 2015, In : Cell Metabolism. 21, 3, p. 428-442 15 p.

Research output: Contribution to journalArticle

Protein Subunits
Protein Biosynthesis
Muscular Diseases
Transfer RNA
Mitochondrial Diseases
2 Citations (Scopus)

Improvement of plasma biomarkers after switching stroke patients from other angiotensin II type i receptor blockers to olmesartan

Tada, Y., Yagi, K., Uno, M., Matsushita, N., Kanematsu, Y., Kuwayama, K., Shimada, K., Nishi, K., Hirasawa, M., Satomi, J., Kitazato, K. T., Kageji, T., Matsuura, E. & Nagahiro, S., Jul 1 2015, In : Journal of Stroke and Cerebrovascular Diseases. 24, 7, p. 1487-1492 6 p.

Research output: Contribution to journalArticle

Angiotensin Receptor Antagonists
Biomarkers
Stroke
Blood Pressure
Peroxiredoxins
5 Citations (Scopus)

In situ X-ray diffraction observation of smectite hydration under constant volume

Takahashi, Y., Kawamura, K., Sato, T., Kobayashi, I. & Ichikawa, Y., Dec 2 2015, In : Journal of Nuclear Science and Technology. 52, 12, p. 1470-1479 10 p.

Research output: Contribution to journalArticle

montmorillonite
Hydration
hydration
X ray diffraction
swelling
12 Citations (Scopus)

Positron emission tomography to elucidate pharmacokinetic differences of regioisomeric retinoid x receptor agonists

Kobayashi, T., Furusawa, Y., Yamada, S., Akehi, M., Takenaka, F., Sasaki, T., Akahoshi, A., Hanada, T., Matsuura, E., Hirano, H., Tai, A. & Kakuta, H., Mar 12 2015, In : ACS Medicinal Chemistry Letters. 6, 3, p. 334-338 5 p.

Research output: Contribution to journalArticle

Positron emission tomography
Pharmacokinetics
Retinoids
Positron-Emission Tomography
Blood
4 Citations (Scopus)

Possible role of cortactin phosphorylation by protein kinase Cα in actin-bundle formation at growth cone

Yamada, H., Kikuchi, T., Masumoto, T., Wei, F. Y., Abe, T., Takeda, T., Nishiki, T., Tomizawa, K., Watanabe, M., Matsui, H. & Takei, K., Sep 1 2015, In : Biology of the Cell. 107, 9, p. 319-330 12 p.

Research output: Contribution to journalArticle

Cortactin
Growth Cones
Protein Kinase C
Actins
Phosphorylation
17 Citations (Scopus)

Tumor-specific delivery of BSH-3R for boron neutron capture therapy and positron emission tomography imaging in a mouse brain tumor model

Iguchi, Y., Michiue, H., Kitamatsu, M., Hayashi, Y., Takenaka, F., Nishiki, T. & Matsui, H., Jul 1 2015, In : Biomaterials. 56, p. 10-17 8 p.

Research output: Contribution to journalArticle

Boron Neutron Capture Therapy
Positron emission tomography
Boron
Brain Neoplasms
Positron-Emission Tomography
2014
5 Citations (Scopus)

7-Ketocholesteryl-9-carboxynonanoate enhances ATP binding cassette transporter A1 expression mediated by PPARγ in THP-1 macrophages

Chi, Y., Wang, L., Liu, Y., Ma, Y., Wang, R., Han, X., Qiao, H., Lin, J., Matsuura, E., Liu, S. & Liu, Q., 2014, In : Atherosclerosis. 234, 2, p. 461-468 8 p.

Research output: Contribution to journalArticle

ATP-Binding Cassette Transporters
PPAR gamma
Macrophages
Cholesterol
Apolipoprotein A-I
1 Citation (Scopus)

Atherosclerosis in primary antiphospholipid syndrome: Summary of clinical and pathogenic evidence

Ames, P. R. J., Lopez, L. R., Matsuura, E. & Margarita, A., 2014, In : Journal of Clinical and Experimental Cardiology. 5, 2

Research output: Contribution to journalArticle

Antiphospholipid Syndrome
Atherosclerosis
Antiphospholipid Antibodies
Habitual Abortion
Immune System Diseases
1 Citation (Scopus)

Calculation of permeability of clay mineral in natural slope by using numerical analysis

Choi, J., Chae, B. G., Kawamura, K. & Ichikawa, Y., Jan 1 2014, Landslide Science for a Safer Geoenvironment: Volume 2: Methods of Landslide Studies. Springer International Publishing, p. 21-25 5 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

clay mineral
permeability
clay
snowmelt
viscosity
1 Citation (Scopus)
Testicular Neoplasms
Antigens
Neoplasms
Carcinoma, squamous cell of head and neck
Neoplasm Antigens
7 Citations (Scopus)

Ectopic calcification: Importance of common nanoparticle scaffolds containing oxidized acidic lipids

Kumon, H., Matsuura, E., Nagaoka, N., Yamamoto, T., Uehara, S., Araki, M., Matsunami, Y., Kobayashi, K. & Matsumoto, A., Feb 2014, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 10, 2, p. 441-450 10 p.

Research output: Contribution to journalArticle

Calcifying Nanoparticles
Scaffolds
Nanoparticles
Lipids
Byproducts
25 Citations (Scopus)

Estimation of soil-to-plant transfer factors of radiocesium in 99 wild plant species grown in arable lands 1 year after the Fukushima 1 Nuclear Power Plant accident

Yamashita, J., Enomoto, T., Yamada, M., Ono, T., Hanafusa, T., Nagamatsu, T., Sonoda, S. & Yamamoto, Y., Jan 2014, In : Journal of Plant Research. 127, 1, p. 11-22 12 p.

Research output: Contribution to journalArticle

nuclear power
power plants
wild plants
accidents
arable soils
72 Citations (Scopus)

Is atherosclerosis an autoimmune disease?

Matsuura, E., Atzeni, F., Sarzi-Puttini, P., Turiel, M., Lopez, L. R. & Nurmohamed, M. T., Mar 18 2014, In : BMC Medicine. 12, 1, 47.

Research output: Contribution to journalArticle

Autoimmune Diseases
Atherosclerosis
Autoimmunity
LDL Lipoproteins
Innate Immunity
8 Citations (Scopus)

Methylphenidate improves learning impairments and hyperthermia-induced seizures caused by an Scn1a mutation

Ohmori, I., Kawakami, N., Liu, S., Wang, H., Miyazaki, I., Asanuma, M., Michiue, H., Matsui, H., Mashimo, T. & Oouchida, M., Oct 1 2014, In : Epilepsia. 55, 10, p. 1558-1567 10 p.

Research output: Contribution to journalArticle

Methylphenidate
Induced Hyperthermia
Seizures
Learning
Mutation
dry density
finite element method
Porous materials
Molecular dynamics
porous medium
1 Citation (Scopus)

Numerical evaluation of a multiple soil barrier system preventing water infiltration

Takayama, Y., Ikuta, Y., Iizuka, A., Kawai, K., Taki, T., Sakao, R. & Ichikawa, Y., 2014, Unsaturated Soils: Research and Applications - Proceedings of the 6th International Conference on Unsaturated Soils, UNSAT 2014. Taylor and Francis - Balkema, Vol. 1. p. 659-665 7 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

infiltration (hydrology)
infiltration
bentonite
rain intensity
granite soils
10 Citations (Scopus)

Recombinant Domain V of β2-Glycoprotein I Inhibits the Formation of Atherogenic oxLDL/β2-Glycoprotein I Complexes

Li, J., Chi, Y., Liu, S., Wang, L., Wang, R., Han, X., Matsuura, E. & Liu, Q., Aug 1 2014, In : Journal of Clinical Immunology. 34, 6, p. 669-676 8 p.

Research output: Contribution to journalArticle

LDL Lipoproteins
Glycoproteins
Antiphospholipid Syndrome
Foam Cells
Atherosclerosis
4 Citations (Scopus)
Vincristine
Prednisolone
Methotrexate
Doxorubicin
Cyclophosphamide
29 Citations (Scopus)

The acceleration of boron neutron capture therapy using multi-linked mercaptoundecahydrododecaborate (BSH) fused cell-penetrating peptide

Michiue, H., Sakurai, Y., Kondo, N., Kitamatsu, M., Bin, F., Nakajima, K., Hirota, Y., Kawabata, S., Nishiki, T., Ohmori, I., Tomizawa, K., Miyatake, S. I., Ono, K. & Matsui, H., Mar 2014, In : Biomaterials. 35, 10, p. 3396-3405 10 p.

Research output: Contribution to journalArticle

Boron Neutron Capture Therapy
Cell-Penetrating Peptides
Boron
Peptides
Neutrons
22 Citations (Scopus)

The transdermal inhibition of melanogenesis by a cell-membrane-permeable peptide delivery system based on poly-arginine

Ookubo, N., Michiue, H., Kitamatsu, M., Kamamura, M., Nishiki, T., Ohmori, I. & Matsui, H., 2014, In : Biomaterials. 35, 15, p. 4508-4516 9 p.

Research output: Contribution to journalArticle

Arginine
Cell membranes
Peptides
Cell Membrane
Melanin

The use of the ubiquitin-proteasome system in neurosurgery and the clinical applications of protein therapy

Michiue, H. & Date, I., Oct 1 2014, In : Neurological Surgery. 42, 10, p. 899-906 8 p.

Research output: Contribution to journalArticle

Tumor Suppressor Protein p53
Neurosurgery
Proteasome Endopeptidase Complex
Drug Delivery Systems
Ubiquitin
2013
6 Citations (Scopus)

7-Ketocholesteryl-9-carboxynonanoate enhances the expression of ATP-binding cassette transporter A1 via CD36

Li, W., Wang, D., Chi, Y., Wang, R., Zhang, F., Ma, G., Chen, Z., Li, J., Liu, Z., Matsuura, E. & Liu, Q., Jan 2013, In : Atherosclerosis. 226, 1, p. 102-109 8 p.

Research output: Contribution to journalArticle

ATP-Binding Cassette Transporters
Caveolin 1
Mitogen-Activated Protein Kinase 3
Mitogen-Activated Protein Kinase 1
Protein Kinases
7 Citations (Scopus)

A purification system for 64Cu produced by a biomedical cyclotron for antibody PET imaging

Toyota, T., Hanafusa, T., Oda, T., Koumura, I., Sasaki, T., Matsuura, E., Kumon, H., Yano, T. & Ono, T., 2013, In : Journal of Radioanalytical and Nuclear Chemistry. 298, 1, p. 295-300 6 p.

Research output: Contribution to journalArticle

Anion Exchange Resins
Cyclotrons
Radiopharmaceuticals
Ion Exchange
Antibodies
18 Citations (Scopus)

Bimodal anti-glioma mechanisms of cilengitide demonstrated by novel invasive glioma models

Onishi, M., Ichikawa, T., Kurozumi, K., Fujii, K., Yoshida, K., Inoue, S., Michiue, H., Chiocca, E. A., Kaur, B. & Date, I., Apr 2013, In : Neuropathology. 33, 2, p. 162-174 13 p.

Research output: Contribution to journalArticle

Glioma
Neoplasms
Integrins
Endothelial Cells
Nude Rats
19 Citations (Scopus)

CACNA1A variants may modify the epileptic phenotype of Dravet syndrome

Ohmori, I., Oouchida, M., Kobayashi, K., Jitsumori, Y., Mori, A., Michiue, H., Nishiki, T., Ohtsuka, Y. & Matsui, H., Feb 2013, In : Neurobiology of Disease. 50, 1, p. 209-217 9 p.

Research output: Contribution to journalArticle

Myoclonic Epilepsy
Phenotype
Mutation
NAV1.1 Voltage-Gated Sodium Channel
Seizures