Neutron Therapy Research Center

Research Output

2020

Deep Learning of Cancer Stem Cell Morphology Using Conditional Generative Adversarial Networks

Aida, S., Okugawa, J., Fujisaka, S., Kasai, T., Kameda, H. & Sugiyama, T., Jun 19 2020, In : Biomolecules. 10, 6

Research output: Contribution to journalArticle

Open Access
Open Access

Rapid and specific detection of oxidized LDL/β2GPI complexes via facile lateral flow immunoassay

Tan, X. W., Takenaka, F., Takekawa, H. & Mastuura, E., Jun 2020, In : Heliyon. 6, 6, e04114.

Research output: Contribution to journalArticle

Open Access

Sera anti-p53 antibody provides new information which explains the link between diabetes and cancer

Sauriasari, R., Sekar, A. P., Aisyah, N., Syahdi, R. R. & Matsuura, E., 2020, In : Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 13, p. 325-331 7 p.

Research output: Contribution to journalArticle

Open Access

Tithonia diversifolia-derived orizabin suppresses cell adhesion, differentiation, and oxidized LDL accumulation by Akt signaling suppression via PTEN promotion in THP-1 cells

Ide, M., Yoshida, I., Kumagai, M., Mishima, T., Takahashi, Y., Fujita, K., Igarashi, T. & Matsuura, E., Jul 1 2020, In : Journal of Food Biochemistry. 44, 7, e13268.

Research output: Contribution to journalArticle

2019

A culture substratum with net-like polyamide fibers promotes the differentiation of mouse and human pluripotent stem cells to insulin-producing cells

Kaitsuka, T., Kojima, R., Kawabe, M., Noguchi, H., Shiraki, N., Kume, S. & Tomizawa, K., Jun 19 2019, In : Biomedical materials (Bristol, England). 14, 4, 1 p.

Research output: Contribution to journalArticle

A leucine zipper-based peptide hybrid delivers functional Nanog protein inside the cell nucleus

Hakata, Y., Michiue, H., Ohtsuki, T., Miyazawa, M. & Kitamatsu, M., Jan 1 2019, In : Bioorganic and Medicinal Chemistry Letters.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Clinical significance of buccal branches of the facial nerve and their relationship with the emergence of Stensen's duct: An anatomical study on adult Taiwanese cadavers

Tsai, C. H., Ting, C. C., Wu, S. Y., Chiu, J. Y., Chen, H., Igawa, K., Lan, T. H., Chen, C. M., Takato, T., Hoshi, K. & Ko, E. C., Nov 2019, In : Journal of Cranio-Maxillofacial Surgery. 47, 11, p. 1809-1818 10 p.

Research output: Contribution to journalArticle

Mitochondrial localization of PABPN1 in oculopharyngeal muscular dystrophy

Doki, T., Yamashita, S., Wei, F. Y., Hara, K., Yamamoto, T., Zhang, Z., Zhang, X., Tawara, N., Hino, H., Uyama, E., Kurashige, T., Maruyama, H., Tomizawa, K. & Ando, Y., Nov 1 2019, In : Laboratory Investigation. 99, 11, p. 1728-1740 13 p.

Research output: Contribution to journalArticle

Novel single-chain variant of antibody against mesothelin established by phage library

Yakushiji, H., Kobayashi, K., Takenaka, F., Kishi, Y., Shinohara, M., Akehi, M., Sasaki, T., Ohno, E. & Matsuura, E., Sep 1 2019, In : Cancer Science. 110, 9, p. 2722-2733 12 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Phosphorylation of cortactin by cyclin-dependent kinase 5 modulates actin bundling by the dynamin 1-cortactin ring-like complex and formation of filopodia and lamellipodia in NG108-15 glioma-derived cells

Abe, T., La, T. M., Miyagaki, Y., Oya, E., Wei, F. Y., Sumida, K., Fujise, K., Takeda, T., Tomizawa, K., Takei, K. & Yamada, H., Feb 2019, In : International journal of oncology. 54, 2, p. 550-558 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Use of DNA-generated gold nanoparticles to radiosensitize and eradicate radioresistant glioma stem cells

Kunoh, T., Shimura, T., Kasai, T., Matsumoto, S., Mahmud, H., Khayrani, A. C., Seno, M., Kunoh, H. & Takada, J., Feb 1 2019, In : Nanotechnology. 30, 5, 055101.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2018

Boron neutron capture therapy combined with early successive bevacizumab treatments for recurrent malignant gliomas – A pilot study

Shiba, H., Takeuchi, K., Hiramatsu, R., Furuse, M., Nonoguchi, N., Kawabata, S., Kuroiwa, T., Kondo, N., Sakurai, Y., Suzuki, M., Ono, K., Oue, S., Ishikawa, E., Michiue, H. & Miyatake, S. I., Jan 1 2018, In : neurologia medico-chirurgica. 58, 12, p. 487-494 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Fibroblast growth factor 13 regulates glioma cell invasion and is important for bevacizumab-induced glioma invasion

Otani, Y., Ichikawa, T., Kurozumi, K., Inoue, S., Ishida, J., Oka, T., Shimizu, T., Tomita, Y., Hattori, Y., Uneda, A., Matsumoto, Y., Michiue, H. & Date, I., Feb 8 2018, In : Oncogene. 37, 6, p. 777-786 10 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

HSP-enriched properties of extracellular vesicles involve survival of metastatic oral cancer cells

Ono, K., Eguchi, T., Sogawa, C., Calderwood, S. K., Futagawa, J., Kasai, T., Seno, M., Okamoto, K., Sasaki, A. & Kozaki, K. I., Sep 2018, In : Journal of Cellular Biochemistry. 119, 9, p. 7350-7362 13 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Mutants of β2-glycoprotein I: Their features and potent applications

Shen, L., Azmi, N. U., Tan, X. W., Yasuda, S., Wahyuningsih, A. T., Inagaki, J., Kobayashi, K., Ando, E., Sasaki, T. & Matsuura, E., Aug 2018, In : Best Practice and Research: Clinical Rheumatology. 32, 4, p. 572-590 19 p.

Research output: Contribution to journalReview article

1 Citation (Scopus)

Oxytocin Inhibits Corticosterone-induced Apoptosis in Primary Hippocampal Neurons

Latt, H. M., Matsushita, H., Morino, M., Koga, Y., Michiue, H., Nishiki, T., Tomizawa, K. & Matsui, H., May 21 2018, In : Neuroscience. 379, p. 383-389 7 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Physical modification of carbon nanotubes with a dendrimer bearing terminal mercaptoundecahydrododecaborates (Na2B12H11S)

Yamagami, M., Tajima, T., Ishimoto, K., Miyake, H., Michiue, H. & Takaguchi, Y., Dec 2018, In : Heteroatom Chemistry. 29, 5-6, e21467.

Research output: Contribution to journalArticle

Regulation of mitochondrial iron homeostasis by sideroflexin 2

Mon, E. E., Wei, F. Y., Ahmad, R. N. R., Yamamoto, T., Moroishi, T. & Tomizawa, K., Jan 1 2018, (Accepted/In press) In : Journal of Physiological Sciences.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Sirtuin 7 is involved in the consolidation of fear memory in mice

Islam, M. S., Wei, F. Y., Ohta, K., Shigematsu, N., Fukuda, T., Tomizawa, K., Yoshizawa, T. & Yamagata, K., Jan 1 2018, In : Biochemical and Biophysical Research Communications. 495, 1, p. 261-266 6 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Suppression effect on IFN-γ of adipose tissue-derived mesenchymal stem cells isolated from β2-microglobulin-deficient mice

Masuda, J., Takayama, E., Ichinohe, T., Strober, W., Mizuno-Kamiya, M., Ikawa, T., Kitani, A., Kawaki, H., Fuss, I., Kawamoto, H., Seno, A., Vaidyanath, A., Umemura, N., Mizutani, A., Kasai, T., Honjo, Y., Satoh, A., Murakami, H., Katsura, Y., Kondoh, N. & 1 others, Seno, M., Nov 2018, In : Experimental and Therapeutic Medicine. 16, 5, p. 4277-4282 6 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2017

Anti-high Mobility Group Box 1 Antibody Ameliorates Albuminuria in MRL/lpr Lupus-Prone Mice

Watanabe, H., Watanabe, K. S., Liu, K., Hiramatsu, S., Zeggar, S., Katsuyama, E., Tatebe, N., Akahoshi, A., Takenaka, F., Hanada, T., Akehi, M., Sasaki, T., Sada, K. E., Matsuura, E., Nishibori, M. & Wada, J., Sep 15 2017, In : Molecular Therapy - Methods and Clinical Development. 6, p. 31-39 9 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Cdk5rap1-mediated 2-methylthio-N6-isopentenyladenosine modification is absent from nuclear-derived RNA species

Fakruddin, M., Wei, F. Y., Emura, S., Matsuda, S., Yasukawa, T., Kang, D. & Tomizawa, K., 2017, In : Nucleic acids research. 45, 20, p. 11954-11961 8 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics

Akaike, T., Ida, T., Wei, F. Y., Nishida, M., Kumagai, Y., Alam, M. M., Ihara, H., Sawa, T., Matsunaga, T., Kasamatsu, S., Nishimura, A., Morita, M., Tomizawa, K., Nishimura, A., Watanabe, S., Inaba, K., Shima, H., Tanuma, N., Jung, M., Fujii, S. & 6 others, Watanabe, Y., Ohmuraya, M., Nagy, P., Feelisch, M., Fukuto, J. M. & Motohashi, H., Dec 1 2017, In : Nature communications. 8, 1, 1177.

Research output: Contribution to journalArticle

105 Citations (Scopus)

Inflammasomes and Inflammatory Cytokines in Early Atherosclerosis

Matsuura, E., Tan, X. W., Shen, L. H., Azmi, N. U. & Lopez, L. R., 2017, Handbook of Systemic Autoimmune Diseases. Elsevier Ltd, p. 155-167 13 p. (Handbook of Systemic Autoimmune Diseases; vol. 14).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

In vitro analysis of radioprotective effect of monoterpenes

Kudo, K. I., Hanafusa, T. & Ono, T., May 4 2017, (Accepted/In press) In : Journal of Radioanalytical and Nuclear Chemistry. p. 1-6 6 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

PIK3R1Met326Ile germline mutation correlates with cysteine-rich protein 61 expression and poor prognosis in glioblastoma

Otani, Y., Ishida, J., Kurozumi, K., Oka, T., Shimizu, T., Tomita, Y., Hattori, Y., Uneda, A., Matsumoto, Y., Michiue, H., Tomida, S., Matsubara, T., Ichikawa, T. & Date, I., Dec 1 2017, In : Scientific reports. 7, 1, 7391.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Reactive sulfur species regulate tRNA methylthiolation and contribute to insulin secretion

Takahashi, N., Wei, F. Y., Watanabe, S., Hirayama, M., Ohuchi, Y., Fujimura, A., Kaitsuka, T., Ishii, I., Sawa, T., Nakayama, H., Akaike, T. & Tomizawa, K., 2017, In : Nucleic acids research. 45, 1, p. 435-445 11 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Synergistic effects of the immune checkpoint inhibitor CTLA-4 combined with the growth inhibitor lycorine in a mouse model of renal cell carcinoma

Li, X., Xu, P., Wang, C., Xu, N., Xu, A., Xu, Y., Sadahira, T., Araki, M., Wada, K., Matsuura, E., Watanabe, M., Zheng, J., Sun, P., Huang, P., Nasu, Y. & Liu, C., 2017, In : Oncotarget. 8, 13, p. 21177-21186 10 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Synthesis of L-cysteine derivatives containing stable sulfur isotopes and application of this synthesis to reactive sulfur metabolome

Ono, K., Jung, M., Zhang, T., Tsutsuki, H., Sezaki, H., Ihara, H., Wei, F. Y., Tomizawa, K., Akaike, T. & Sawa, T., May 1 2017, In : Free Radical Biology and Medicine. 106, p. 69-79 11 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

The immunological impact of chemotherapy on the tumor microenvironment of oral squamous cell carcinoma

Takakura, H., Domae, S., Ono, T. & Sasaki, A., 2017, In : Acta medica Okayama. 71, 3, p. 219-226 8 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

The lipid moiety 7-ketocholesteryl-9-carboxynonanoate mediates binding interaction of oxLDL to LOX-1 and upregulates ABCA1 expression through PPARγ

Li, J., Xiu, Z., Wang, R., Yu, C., Chi, Y., Qin, J., Fu, C., Matsuura, E. & Liu, Q., May 15 2017, In : Life Sciences. 177, p. 27-40 14 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2016

Fluvoxamine, an anti-depressant, inhibits human glioblastoma invasion by disrupting actin polymerization

Hayashi, K., Michiue, H., Yamada, H., Takata, K., Nakayama, H., Wei, F. Y., Fujimura, A., Tazawa, H., Asai, A., Ogo, N., Miyachi, H., Nishiki, T. I., Tomizawa, K., Takei, K. & Matsui, H., Mar 18 2016, In : Scientific reports. 6, 23372.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Oxytocin Protects against Stress-Induced Cell Death in Murine Pancreatic β-Cells

Watanabe, S., Wei, F. Y., Matsunaga, T., Matsunaga, N., Kaitsuka, T. & Tomizawa, K., May 4 2016, In : Scientific reports. 6, 25185.

Research output: Contribution to journalArticle

19 Citations (Scopus)
2015

A cautionary tale: the non-causal association between type 2 diabetes risk SNP, rs7756992, and levels of non-coding RNA, CDKAL1-v1

Locke, J. M., Wei, F. Y., Tomizawa, K., Weedon, M. N. & Harries, L. W., Mar 6 2015, In : Diabetologia. 58, 4, p. 745-748 4 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

A finite difference method for elastic wave scattering by a planar crack with contacting faces

Kimoto, K. & Ichikawa, Y., Jan 1 2015, In : Wave Motion. 52, p. 120-137 18 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

A new theoretical mineral dissolution rate equation for physicochemical factors

Choi, J., Ichikawa, Y., Kimoto, K. & Chae, B. G., 2015, In : Geochemical Journal. 49, 5, p. 549-557 9 p.

Research output: Contribution to journalArticle

A novel leucine zipper motif-based hybrid peptide delivers a functional peptide cargo inside cells

Hakata, Y., Tsuchiya, S., Michiue, H., Ohtsuki, T., Matsui, H., Miyazawa, M. & Kitamatsu, M., Jan 7 2015, In : Chemical Communications. 51, 2, p. 413-416 4 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Cdk5rap1-mediated 2-methylthio modification of mitochondrial tRNAs governs protein translation and contributes to myopathy in mice and humans

Wei, F. Y., Zhou, B., Suzuki, T., Miyata, K., Ujihara, Y., Horiguchi, H., Takahashi, N., Xie, P., Michiue, H., Fujimura, A., Kaitsuka, T., Matsui, H., Koga, Y., Mohri, S., Suzuki, T., Oike, Y. & Tomizawa, K., Mar 3 2015, In : Cell Metabolism. 21, 3, p. 428-442 15 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Cell-penetrating peptide as a means of directing the differentiation of induced-pluripotent stem cells

Kaitsuka, T. & Tomizawa, K., Nov 6 2015, In : International journal of molecular sciences. 16, 11, p. 26667-26676 10 p.

Research output: Contribution to journalReview article

10 Citations (Scopus)

Positron emission tomography to elucidate pharmacokinetic differences of regioisomeric retinoid x receptor agonists

Kobayashi, T., Furusawa, Y., Yamada, S., Akehi, M., Takenaka, F., Sasaki, T., Akahoshi, A., Hanada, T., Matsuura, E., Hirano, H., Tai, A. & Kakuta, H., Mar 12 2015, In : ACS Medicinal Chemistry Letters. 6, 3, p. 334-338 5 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Possible role of cortactin phosphorylation by protein kinase Cα in actin-bundle formation at growth cone

Yamada, H., Kikuchi, T., Masumoto, T., Wei, F. Y., Abe, T., Takeda, T., Nishiki, T., Tomizawa, K., Watanabe, M., Matsui, H. & Takei, K., Sep 1 2015, In : Biology of the Cell. 107, 9, p. 319-330 12 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2014

7-Ketocholesteryl-9-carboxynonanoate enhances ATP binding cassette transporter A1 expression mediated by PPARγ in THP-1 macrophages

Chi, Y., Wang, L., Liu, Y., Ma, Y., Wang, R., Han, X., Qiao, H., Lin, J., Matsuura, E., Liu, S. & Liu, Q., Jun 2014, In : Atherosclerosis. 234, 2, p. 461-468 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

A Cancer Stem Cell Model: An Insight into the Conversion of Induced Pluripotent Stem Cells to Cancer Stem-Like Cells

Mizutani, A., Chen, L., Kasai, T., Kudoh, T., Murakami, H., Fu, L. & Seno, M., Apr 14 2014, Cancer Stem Cells. Wiley Blackwell, Vol. 9781118356166. p. 79-87 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Atherosclerosis in primary antiphospholipid syndrome: Summary of clinical and pathogenic evidence

Ames, P. R. J., Lopez, L. R., Matsuura, E. & Margarita, A., Feb 2014, In : Journal of Clinical and Experimental Cardiology. 5, 2

Research output: Contribution to journalReview article

1 Citation (Scopus)

Bacteria: Prospective savior in battle against cancer

Nair, N., Kasai, T. & Seno, M., Nov 1 2014, In : Anticancer research. 34, 11, p. 6289-6296 8 p.

Research output: Contribution to journalReview article

9 Citations (Scopus)

Calculation of permeability of clay mineral in natural slope by using numerical analysis

Choi, J., Chae, B. G., Kawamura, K. & Ichikawa, Y., Jan 1 2014, Landslide Science for a Safer Geoenvironment: Volume 2: Methods of Landslide Studies. Springer International Publishing, p. 21-25 5 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Cancer stem cells converted from pluripotent stem cells and the cancerous niche

Kasai, T., Chen, L., Mizutani, A., Kudoh, T., Murakami, H., Fu, L. & Seno, M., 2014, In : Journal of Stem Cells and Regenerative Medicine. 10, 1, p. 2-7 6 p.

Research output: Contribution to journalReview article

16 Citations (Scopus)