Advanced Science Research Center

Research Output

2002

Cellular processing of a multibranched lysine core with tumor antigen peptides and presentation of peptide epitopes recognized by cytotoxic T lymphocytes on antigen-presenting cells

Ota, S., Ono, T., Morita, A., Uenaka, A., Harada, M. & Nakayama, E., Mar 1 2002, In : Cancer Research. 62, 5, p. 1471-1476 6 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Growth inhibition of mammalian cells by eosinophil cationic protein

Maeda, T., Kitazoe, M., Tada, H., De Llorens, R., Salomon, D. S., Ueda, M., Yamada, H. & Seno, M., Feb 9 2002, In : European Journal of Biochemistry. 269, 1, p. 307-316 10 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)

Occurrence of tumor antigen pRL1a specific CD8 T cells in spleen cells from syngeneic BALB/c, semiallogeneic (BALB/c x C57BL/6)F1 and allogeneic C57BL/6 mice.

Hata, H., Uenaka, A., Takada, I., Kenjo, A., Takahashi, M., Ono, T., Fujita, T. & Nakayama, E., May 2002, In : International journal of oncology. 20, 5, p. 1019-1025 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Optimum modification for the highest cytotoxicity of cationized ribonuclease

Futami, J., Nukui, E., Maeda, T., Kosaka, M., Tada, H., Seno, M. & Yamada, H., Aug 2002, In : Journal of biochemistry. 132, 2, p. 223-228 6 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

RNase 3 (ECP) is an extraordinarily stable protein among human pancreatic-type RNases

Maeda, T., Mahara, K., Kitazoe, M., Futami, J., Takidani, A., Kosaka, M., Tada, H., Seno, M. & Yamada, H., Nov 1 2002, In : Journal of biochemistry. 132, 5, p. 737-742 6 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

SEREX法によるマウス移植腫瘍の抗原解析

Ono, T., 2002, In : 岡山医学会雑誌. Vol.114, p. 125-130 6 p.

Research output: Contribution to journalArticle

2001

ELISPOT cloning of tumor antigens recognized by cytotoxic T-lymphocytes from a cDNA expression library

Uenaka, A., Hata, H., Win, S., Ono, T., Wada, H. & Nakayama, E., Jul 13 2001, In : Cancer Immunity. 1, p. 1-10 10 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Generation of cytotoxic T lymphocytes against autologous lung cancer cells resistant to apoptosis

Hiraki, A., Ono, T., Tanaka, M., Kiura, K., Ueoka, H., Kawai, H., Harada, M., Nakayama, E. & Noguchi, Y., Nov 24 2001, In : Anticancer research. 21, 4 A, p. 2561-2568 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Identification of proacrosin binding protein sp32 precursor as a human cancer/testis antigen

Ono, T., Kurashige, T., Harada, N., Noguchi, Y., Saika, T., Niikawa, N., Aoe, M., Nakamura, S., Higashi, T., Hiraki, A., Wada, H., Kumon, H., Old, L. J. & Nakayama, E., Mar 13 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 6, p. 3282-3287 6 p.

Research output: Contribution to journalArticle

95 Citations (Scopus)

Ny-eso-1 expression and immunogenicity associated with transitional cell carcinoma: Correlation with tumor grade

Kurashige, T., Noguchi, Y., Saika, T., Ono, T., Nagata, Y., Jungbluth, A., Ritter, G., Chen, Y. T., Stockert, E., Tsushima, T., Kumon, H., Old, L. J. & Nakayama, E., Jun 15 2001, In : Cancer Research. 61, 12, p. 4671-4674 4 p.

Research output: Contribution to journalArticle

109 Citations (Scopus)
87 Citations (Scopus)

Sex-related differences in the initiation of allergic rhinitis in mice

Yamatomo, T., Okano, M., Ono, T., Nakayama, E., Yoshino, T., Satoskar, A. R., Harn, D. A. & Nishizaki, K., Jun 21 2001, In : Allergy: European Journal of Allergy and Clinical Immunology. 56, 6, p. 525-531 7 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)
2000
74 Citations (Scopus)

Convenient and efficient in vitro folding of disulfide-containing globular protein from crude bacterial inclusion bodies

Futami, J., Tsushima, Y., Tada, H., Seno, M. & Yamada, H., Jan 1 2000, In : Journal of biochemistry. 127, 3, p. 435-441 7 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Molecular cloning and expression of rat betacellulin cDNA

Tada, H., Seno, M., Yamada, H., Sasada, R. & Igarashi, K., Jun 21 2000, In : Biochimica et Biophysica Acta - Gene Structure and Expression. 1492, 1, p. 285-288 4 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Preparation and enzymatic recognition of guanine lesions induced by nitrogen oxides.

Masaoka, A., Terato, H., Honsho, A., Ohyama, Y., Suzuki, T., Yamada, M., Makino, K. & Ide, H., 2000, In : Nucleic acids symposium series. 44, p. 87-88 2 p.

Research output: Contribution to journalArticle

Open Access

Serological analysis of BALB/c methylcholanthrene sarcoma Meth A by SEREX: Identification of a cancer/testis antigen

Ono, T., Sato, S., Kimura, N., Tanaka, M., Shibuya, A., Old, L. J. & Nakayama, E., Dec 15 2000, In : International Journal of Cancer. 88, 6, p. 845-851 7 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Stabilization of human RNase 1 by introduction of a disulfide bond between residues 4 and 118

Futami, J., Tada, H., Seno, M., Ishikami, S. & Yamada, H., Jan 1 2000, In : Journal of biochemistry. 128, 2, p. 245-250 6 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Three-dimensional crystal structure of human eosinophil cationic protein (RNase 3) at 1.75 Å resolution

Mallorquí-Fernández, G., Pous, J., Peracaula, R., Aymamí, J., Maeda, T., Tada, H., Yamada, H., Seno, M., De Llorens, R., Gomis-Rüth, F. X. & Coll, M., Jul 28 2000, In : Journal of Molecular Biology. 300, 5, p. 1297-1307 11 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)
1999

Identification of tumor rejection antigen peptide recognized by cytotoxic T lymphocytes on murine leukemia RL♂1 and the effect of vaccination

Nakayama, E., Uenaka, A., Ono, T. & Aji, T., Dec 1 1999, In : Gann Monographs on Cancer Research. 48, p. 61-70 10 p.

Research output: Contribution to journalReview article

Immunohistochemical localization of betacellulin, a new member of the EGF family, in normal human pancreas and islet tumor cells

Miyagawa, J. I., Hanafusa, T., Sasada, R., Yamamoto, K., Igarashi, K., Yamamori, K., Seno, M., Tada, H., Nammo, T., Li, M., Yamagata, K., Nakajima, H., Namba, M., Kuwajima, M. & Matsuzawa, Y., Dec 1999, In : Endocrine journal. 46, 6, p. 755-764 10 p.

Research output: Contribution to journalArticle

Open Access
52 Citations (Scopus)

Inhibition of cell growth by a fused protein of human ribonuclease 1 and human basic fibroblast growth factor

Futami, J., Seno, M., Ueda, M., Tada, H. & Yamada, H., Dec 13 1999, In : Protein Engineering. 12, 11, p. 1013-1019 7 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Isolation of MHC class I-restricted tumor antigen peptide and its precursors associated with heat shock proteins hsp70, hsp90, and gp96

Ishii, T., Udono, H., Yamano, T., Ohta, H., Uenaka, A., Toshiro, O., Hizuta, A., Tanaka, N., Srivastava, P. K. & Nakayama, E., Feb 1 1999, In : Journal of Immunology. 162, 3, p. 1303-1309 7 p.

Research output: Contribution to journalArticle

202 Citations (Scopus)

Potential and pH Dependencies of Adsorbed Species of 2-, 4-Pyridinethiol and 2-Pyrimidinethiol on Au(111) Electrode

Taniguchi, I., Yoshimoto, S., Sunatsuki, Y. & Nlshiyama, K., Dec 1999, In : Electrochemistry. 67, 12, p. 1197-1199 3 p.

Research output: Contribution to journalArticle

Open Access
14 Citations (Scopus)

Preparation of DNA containing 7-methylguanine as unique lesions.

Asagoshi, K., Terato, H., Ohyama, Y. & Ide, H., 1999, In : Nucleic acids symposium series. 42, p. 83-84 2 p.

Research output: Contribution to journalArticle

Open Access

Processing and juxtacrine activity of membrane-anchored betacellulin

Tada, H., Sasada, R., Kawaguchi, Y., Kojima, I., Gullick, W. J., Salomon, D. S., Igarashi, K., Seno, M. & Yamada, H., Mar 1 1999, In : Journal of Cellular Biochemistry. 72, 3, p. 423-434 12 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Single amino acid replacements in an antigenic peptide are sufficient to alter the TCR Vβ repertoire of the responding CD8+ cytotoxic lymphocyte population

Kalergis, A. M., Ono, T., Wang, F., DiLorenzo, T. P., Honda, S. & Nathenson, S. G., Jun 15 1999, In : Journal of Immunology. 162, 12, p. 7263-7270 8 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
1998

Alterations in TCR-MHC contacts subsequent to cross-recognition of class I MHC and singly substituted peptide variants

Ono, T., DiLorenzo, T. P., Wang, F., Kalergis, A. M. & Nathenson, S. G., Nov 15 1998, In : Journal of Immunology. 161, 10, p. 5454-5463 10 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

BALB/c 3T3 cells co-expressing FGF-2 and soluble FGF receptor acquire tumorigenicity

Seno, M., Masago, A., Nishimura, A., Tada, H., Kosaka, M., Sasada, R., Igarashi, K., Seno, S. & Yamada, H., Apr 1998, In : Cytokine. 10, 4, p. 290-294 5 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Major histocompatibility complex class I-restricted T cells are required for all but the end stages of diabetes development in nonobese diabetic mice and use a prevalent T cell receptor α chain gene rearrangement

DiLorenzo, T. P., Graser, R. T., Ono, T., Christianson, G. J., Chapman, H. D., Roopenian, D. C., Nathenson, S. G. & Serreze, D. V., Oct 13 1998, In : Proceedings of the National Academy of Sciences of the United States of America. 95, 21, p. 12538-12543 6 p.

Research output: Contribution to journalArticle

Open Access
156 Citations (Scopus)

On defining the rules for interactions between the T cell receptor and its ligand: A critical role for a specific amino acid residue of the T cell receptor β chain

Wang, F., Ono, T., Kalergis, A. M., Zhang, W., DiLorenzo, T. P., Lim, K. & Nathenson, S. G., Apr 28 1998, In : Proceedings of the National Academy of Sciences of the United States of America. 95, 9, p. 5217-5222 6 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Purification and characterization of a recombinant human cripto-1 protein

Seno, M., Desantis, M., Kannan, S., Bianco, C., Tada, H., Kim, N., Kosaka, M., Gullick, W. J., Yamada, H. & Salomon, D. S., Jan 1 1998, In : Growth Factors. 15, 3, p. 215-229 15 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Vaccination with multiple antigen peptide as rejection antigen peptide in murine leukemia

Manki, A., Ono, T., Uenaka, A., Seino, Y. & Nakayama, E., May 1 1998, In : Cancer Research. 58, 9, p. 1960-1964 5 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
1997

Diversity of epitopes recognized by cytotoxic T lymphocytes that are specific for rejection antigen peptide pRL1a presented on BALB/c leukemia RL♂1

Yokoi, T., Uenaka, A., Ono, T., Onizuka, S., Inoue, H. & Nakayama, E., 1997, In : International Immunology. 9, 8, p. 1195-1201 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Efficient production of a functional mouse/human chimeric Fab' against human urokinase-type plasminogen activator by Bacillus brevis

Inoue, Y., Ohta, T., Tada, H., Iwasa, S., Udaka, S. & Yamagata, H., Nov 17 1997, In : Applied Microbiology and Biotechnology. 48, 4, p. 487-492 6 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

電流によって産生を制御される大腸菌タンパク質の同定と解析(共著)

Kosaka, M., 1997, In : 日本分子生物学会年会. 4, 554, p. 771-771 1 p.

Research output: Contribution to journalArticle

1996

Analysis on the cleavage of membrane-bound betacellulin

Tada, H., Seno, M., Kawaguchi, Y., Sasada, R., Igarashi, K. & Yamada, H., Dec 1 1996, In : FASEB Journal. 10, 3, p. A774

Research output: Contribution to journalArticle

Human betacellulin, a member of the EGF family dominantly expressed in pancreas and small intestine, is fully active in a monomeric form

Seno, M., Tada, H., Kosaka, M., Sasada, R., Igarash, K., Shing, Y., Folkman, J., Ueda, M. & Yamada, H., Jan 1 1996, In : Growth Factors. 13, 3-4, p. 181-191 11 p.

Research output: Contribution to journalArticle

70 Citations (Scopus)

Production of murine leukemia RL♂1 rejection antigen peptide pRL1a by proteolysis of natural precursor pRL1b

Ono, T., Uenaka, A. & Nakayama, E., Nov 1996, In : Japanese Journal of Cancer Research. 87, 11, p. 1165-1170 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
1995

Analysis on the Physiological Roles of Soluble FGF Receptor

Tada, H., 1995, In : Default journal. p. 459-459 1 p.

Research output: Contribution to journalArticle

Characterization of Human Betacellulin(jointly worked)

Tada, H., 1995, In : Cell structure and function. 20, 6, p. 568-568 1 p.

Research output: Contribution to journalArticle

Characterization of Human Betacellulin Produced in E.Coli(jointly worked)

Tada, H., 1995, In : Molecular Biology of the Cell. 6, Supplament, p. 126a-126a 1 p.

Research output: Contribution to journalArticle

Molecular cloning and expression of human ribonuclease 4 cDNA

Seno, M., Futami, J. I., Tsushima, Y., Akutagawa, K., Kosaka, M., Tada, H. & Yamada, H., Apr 26 1995, In : BBA - Gene Structure and Expression. 1261, 3, p. 424-426 3 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
31 Citations (Scopus)

Requirement of CD4+ T cells and antigen-presenting cells for primary in vitro generation of CD8+ cytotoxic T cells against L(d)-binding self-peptide p2Ca

Wada, H., Ono, T., Uenaka, A., Monden, M. & Nakayama, E., Jan 1 1995, In : Immunology. 84, 4, p. 633-637 5 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)